INTIMATION FOR BODHIKA SEMINAR                                   25/10/2023

                               DEPARTMENT OF PRASUTI TANTRA & STREEROGA

                                            RASASHASTRA & BHAISHAJYA KALPANA

GOVT. AYURVEDA COLLEGE, THIRUVANANTHAPURAM

NAME  OF  FIRST PRESENTEE:DR. SRUTHI  L R

DISSERTATION TITLE: COMBINED EFFECT OF RAJAPRAVARTINI VATI AND CHIRUVILWADI KASHAYA IN OLIGOMENORRHOEA ASSOCIATED WITH POLYCYSTIC OVARIAN SYNDROME

NAME OF GUIDE:  Dr.  ANILA M  MD (AY)

DATE:25/10/2023

TIME: 2:00-4:00 PM

VENUE: COLLEGE AUDITORIUM

ABSTRACT

Polycystic Ovarian Syndrome is one of the most common metabolic &reproductive disorder among women of reproductive age. Changes in the lifestyle, diet, stress of modern society leads to increase in prevalence of PCOS upto 20-30%. PCOS effects the richness of feminity as infertility stands out as one of its major complications. Oligomenorrhoea is one among the most common presenting complaints in participants diagnosed with PCOS. Although no direct correlation of PCOS is found in ayurvedic classical texts. Etiopathogenesis of nastharthava, arhavakshaya, and vandhya yoni vyapath mentioned in susrutha samhitha can be considered here. Pushpagni jataharini mentioned in Kasyapa samhitha bears some similarity with this disease. Here the combined effect of Rajapravartini vati & chiruvilwadi kashaya in Oligomenorrhoea associated with PCOS were evaluated. The study drug Rajapravartini vati is mentioned under streerogadhikara in bhaishajyaratnavali and Chiruvilwadi kashaya is mentioned under arsas prakaranam in sahasrayogam. The study design is pre and post interventional study with a sample size of 30. Females in age group of 18-40 years diagnosed as having Oligomenorrhoea associated with PCOS as per Rotterdam criteria 2003, satisfying inclusion and exclusion criteria attending the OPD of Dept of Prasutitantra and streeroga, Govt Ayurveda College, Thiruvananthapuram were selected for the study. Their symptoms were assessed before starting the treatment using a case proforma, USG and necessary lab investigations. In this study 125 mg of Rajapravartini vati followed by intake of 48 ml of Chiruvilwadi kashaya twice daily before food were adviced to the participants for 90 days. Administration of drug starts on the 1st day of visit and continued till the onset of next menstrual cycle excluding the 3 days of menstruation for three consecutive cycles. Follow up without medicines was done for next 3 consecutive cycles. Data obtained was analysed statistically. The study drug was found to be effective in normalizing menstrual interval, reducing the ovarian volume and reducing the BMI, without causing changes in duration of menstruation, amount of bleeding and haemoglobin level with in the study period.

 INTIMATION FOR BODHIKA SEMINAR                                       18/10/2023

                             DEPARTMENT OF KAYACHIKITSA & PANCHAKARMA 

GOVT. AYURVEDA COLLEGE, THIRUVANANTHAPURAM

NAME  OF  FIRST PRESENTEE: DR. RESHMI A.S

DISSERTATION TITLE:PHARMACOLOGICAL ACTIVITY OF BRAHMA RASAYANA IN MYOCARDIAL REPERFUSION INJURY IN H9C2 CELL LINE

NAME OF GUIDE:   Dr. MINI V.G M.D (AY)

DATE:18/10/2023  

TIME: 2:00-4:00 PM

VENUE: COLLEGE AUDITORIUM

ABSTRACT

Myocardial Reperfusion Injury refers to damage of cardiac tissue due to restoration of blood to an oxygen deprived myocardium. This may trigger series of cascades such as inflammation and oxidative stress induced oxidative damage that can induce secondary cardiac dysfunction, including myocardial stunning, no-reflow phenomenon, reperfusion arrhythmias, and lethal reperfusion injury which can paradoxically reduce the beneficial effects of myocardial reperfusion and lead to lethal damage to myocardium by the triggering of apoptosis. This can be tackled with antioxidants. Brahma Rasayana being one such formulation, which is thought to bring a positive result in the adverse effects of reperfusion injuries owing to the presence of antioxidants as ingredients.

The main objective of the study was to evaluate the activity of Brahma Rasayana in improving the regenerative potential in Myocardial Reperfusion Injury through invitro study in H9C2 cell line. The protocols adopted were estimation of antioxidant activity, preconditioning and postconditioning to know the response to addition of ischemic buffer, Mitochondrial Membrane Potential (MMP) and Reactive Oxygen Species (ROS). DPPH scavenging assay was chosen for estimation of antioxidant activity. On DPPH free radical scavenging assay, maximum antioxidant activity was observed at the concentration 200 μg/ml with percentage inhibition 65.4592%. In preconditioning, Brahma Rasayana provided maximum average cell viability of 62.81 % at a concentration 25 μg/ml. In postconditioning, the maximum percentage viability was 93.01% obtained at 100 μg/ml. Also, Brahma Rasayana showed reduction in mitochondrial depolarization and ROS production. 

  INTIMATION FOR BODHIKA SEMINAR                                       11/10/2023

                             DEPARTMENT OF KAYACHIKITSA

GOVT. AYURVEDA COLLEGE, THIRUVANANTHAPURAM

NAME  OF  FIRST PRESENTEE: DR.ALCINA VARGHESE

DISSERTATION TITLE:EFFECT OF A SELECTED AYURVEDIC TREATMENT PROTOCOL IN DIABETIC PERIPHERAL NEUROPATHY

NAME OF GUIDE:   Dr. K. AMBIKA MD (AY)

DATE:11/10/2023

TIME: 2:00-4:00 PM

VENUE: COLLEGE AUDITORIUM

ABSTRACT

According to American Diabetes Association, Diabetic peripheral neuropathy (DPN) is ‘’the presence of symptoms or signs of peripheral nerve dysfunction in people with diabetes after exclusion of other causes”. DPN is the most common complication of diabetes mellitus. Globally diabetic neuropathy affects approximately 132 million people (1.9% of the population). DPN is by far the most common of all the diabetic neuropathies. Despite efforts to make an early diagnosis and to halt the progression of diabetic neuropathy, currently there is no effective treatment available at a global level.        In Ayurveda, a clear-cut clinical entity similar to DPN is not seen. When we look in to both, DPN may be considered as later stages of Prameha. Micro and macro vascular changes and neuronal ischemia are the main pathology in diabetic neuropathy which are similar to the rakta dushti and vatadushti .  Here abnormal neurological manifestations are associated with Prameha, a santarpanotha vyadhi, indicate the involvement of avarana pathology. So the study was undertaken in an effort to find an effective Ayurvedic treatment protocol to manage DPN and to provide a better quality of life. It included Deepana Pachana with Vachadi choornam and Nisakathakadi kashayam, Udwartanam with Kolakulathadi choornam, Vicharana snehapanam with Madhuyastyadi tailam in Nisakathakadi kashayam , Abhyanga with Bala tailam and  Usnambu snana , Virechana with Nimbamritaderanda tailam   followed by internal administration of  Vara, Vidanga, Krishna choornam with tailam, ghrita and madhu . Reduction of TCNS score and improvement in   Vibration Perception Threshold (VPT) assessed using Neuropathy Analyser was statistically analyzed and concluded. Statistical analysis showed that there was significant reduction of score in TCNS scale and improvement in VPT assessed through Neuropathy analyzer. Thus the study was concluded to be effective in reducing the signs and symptoms of DPN.

 INTIMATION FOR BODHIKA SEMINAR                                       04/10/2023

                                                DEPARTMENT OF DRAVYAGUNAVIGYAN

GOVT. AYURVEDA COLLEGE, THIRUVANANTHAPURAM

NAME  OF  FIRST PRESENTEE: Dr.HARITHA .N

DISSERTATION TITLE: GENUINENESS OF MARKET SAMPLES OF MUSTA( Cyperus rotundus Linn) IN KERALA

NAME OF GUIDE:  Dr .A.SHAHUL HAMEED  MD(Ay)

DATE:04/10/2023

TIME: 2:00-4:00 PM

VENUE: COLLEGE AUDITORIUM

ABSTRACT

Musta is a rhizomatous perennial herb that grows throughout the country, commonly found in waste grounds, gardens, and roadsides. The rhizome/tuber of Musta is a crucial ingredient in Ayurvedic formulations like Mustakadikwatha, Mustakarishta, Asokarishta etc, offering effective remedies for various ailments such as Jwara, Agnimandya, Ajirna, Swasakasa, Atisara, and more. The Ayurvedic Pharmacopoeia of India has identified the source plant of Musta as Cyperus rotundus Linn., belonging to the Cyperaceae family. Though Cyperus rotundus Linn. is widely present in Kerala, it is not extensively cultivated here. Additionally, there is a notable variation in the market price of Musta. This situation raises concerns about possible adulteration or substitution with lower-quality drugs or those from the same family, which can compromise the safety and efficacy of Ayurvedic formulations. To address these concerns, this study was conducted to determine the authenticity of Musta (Cyperus rotundus Linn.) used in Kerala. For this purpose, three sets of samples were collected from raw drug markets in each zone of Kerala North, Central, and South. Each set of sample included one from a rural market, one from an urban market, and one from a manufacturing unit. These samples were compared with genuine Musta and the standards outlined in the API (Ayurvedic Pharmacopoeia of India) through pharmacognostical and various physicochemical evaluations. Organoleptic evaluation revealed slight differences among the samples in terms of size, shape, external surface and internal colour. Results of phytochemical evaluation indicated marked differences between the market samples and the genuine sample in terms of foreign matter, volatile oil content, ash values, extractive values and fibre contents. Qualitative analysis also showed variations in the presence of steroids, phenols, glycosides, tannin and flavonoids among the samples. High-Performance Thin-Layer Chromatography (HPTLC) analysis revealed differences in peaks among the samples. All heavy metals screened were within permissible limits in all samples. Microbial examinations detected presence of mixed colonies of E. coli, Bacillus, and Klebsiella in all samples, and fungal growth of Aspergillus niger in two market samples. Overall, the study findings suggest that Musta available in herbal drug markets in Kerala are genuine but are of inferior quality.