INTIMATION FOR BODHIKA SEMINAR                                   29/11/2023

                                DEPARTMENT OF SALYATANTHRA&SAMHITHA SIDDANTHAM

GOVT. AYURVEDA COLLEGE, THIRUVANANTHAPURAM

NAME  OF  FIRST PRESENTEE:Dr. SHALU

DISSERTATION TITLE:A CLINICAL STUDY TO EVALUATE THE EFFECT OF AGNIKARMA WITH KSHOUDRA OVER ANKLE AND FOOT IN SCIATICA DUE TO L4-L5, L5-S1 INTERVERTEBRAL DISC PROLAPSE

NAME OF GUIDE:   DR. P Benedict MD(AY)

DATE:29/11/2023

TIME: 2:00-4:00 PM

VENUE: COLLEGE AUDITORIUM

                                                        ABSTRACT

Sciatica is a syndrome characterized by pain radiating from the lowback into the buttock and into the lower extremities along its posterior or lateral aspect and most commonly caused by prolapse of lumbar intervertebral disc. The term is also used to refer The pain anywhere along the course of sciatic nerve. Conservative treatment for sciatica is primarily aimed at pain reduction, either by analgesics or by reducing pressure on the nerve root. For patients who fail to respond to conservative treatment, surgery is the alternative. Sciatica can be correlated with Gridhrasi mentioned under vatavyadhi in ayurvedic classics. It is a snayugatha disease characterized by stiffness, pricking pain and tingling sensation starting from low back and radiating downwards to buttocks, posterior aspect of knee, calf, foot and restricting the lifting of the leg. Various treatment modalities like snehana, swedana, vasthi, siravyadha, and agnikarma are indicated in Gridharsi. Procedures like snehana, swedana, vasthi etc are very effective in Gridhrasi but take more time for pain relief. Agnikarma is the chief para surgical procedure which is very effective in treating conditions of severe pain in skin, muscles, veins, tendons and joints and gives immediate pain relief. According to susrutha, in snayugatha vikara agnikarma can be done with kshoudra, guda and sneha. The present study is to evaluate the effect of agnikarma with kshoudra in sciatica due to L4-L5, L5-S1 intervertebral disc prolapse, at the tender spots of ankle and foot of affected lower limb.

     Participants satisfying the inclusion and exclusion criteria within age group of 30-60 years were treated with agnikarma using kshoudra over the tender spots of ankle and foot. Assessment were done before treatment, after treatment and follow ups on 7^th and 14^th day. Statistical analysis done and result showed that agnikarma is effective in reducing pain and numbness of sciatica due to L4-L5, L5-S1 intervertebral disc prolapse.

INTIMATION FOR BODHIKA SEMINAR                                   22/11/2023

                                                     DEPARTMENT OF SALYATANTHRA

GOVT. AYURVEDA COLLEGE, THIRUVANANTHAPURAM

NAME  OF  FIRST PRESENTEE:Dr. RENJU L A

DISSERTATION TITLE: CLINICAL STUDY TO EVALUATE THE EFFECT OF SIRAVEDHA IN THE MANAGEMENT OF VISWACHI WITH SPECIAL REFERENCE TO CERVICAL RADICULOPATHY

NAME OF GUIDE:   DR.  REMYA V R MD (AY)

DATE:22/11/2023

TIME: 2:00-4:00 PM

VENUE: COLLEGE AUDITORIUM

                                                        ABSTRACT

                Radiculopathy, commonly referred as pinched nerve, refers to a set of conditions in which one or more nerves are affected and their functioning is hampered. Cervical radiculopathy is a clinical condition resulting from compression of nerve roots due to disc herniation or degenerative stenosis which leads to neck pain, numbness and radiating arm pain in the distribution of the affected nerve root. Often this radicular pain is accompanied by motor or sensory disturbances also. The main treatments available are use of nonsteroidal anti-inflammatory drugs, epidural steroid injection and surgery in the last stages. But the side effects of NSAID’s, incomplete neurologic recovery, loss of full cervical range of movement and surgical complications are the main hurdle in the management of cervical radiculopathy.

               In Ayurvedic classics, clinical picture of cervical radiculopathy can be explained under the heading of viswachi. It is a vatavyadhi mainly affecting the kandaras leading to restricted movements and loss of function of upper limb. Snehana, swedana, nasya etc. are the regular treatment procedures done to alleviate the symptoms of viswachi. But these procedures are time consuming and do not give an instant relief of pain. Even after the complete course of snigdha rooksha chikitsa the symptoms of viswachi may be persisting. In such cases siravedha can make remarkable changes in its clinical picture. According to classics in viswachi, the sira located 4 angula above or below the koorpara sandhi (cephalic vein) is to be punctured. It is a simple, cost effective and less time-consuming procedure which gives immediate relief of symptoms.

              So, the present study was taken to evaluate the effect of siravedha in reducing pain, numbness, disability and tenderness in viswachi with special reference to cervical radiculopathy. Study design was formulated as pre and post interventional study. Sampling method was consecutive sampling and the sample size was 20. Participants between the age group of 30-60 years irrespective of gender diagnosed as having cervical radiculopathy, fulfilling the inclusion and exclusion criteria, attending the OPD and IPD of department of salyatantra, Government Ayurveda college Thiruvananthapuram were taken for the study. A maximum amount of 300 ml of blood was collected from corresponding cephalic vein as a onetime procedure. The findings were recorded and analysed using the most appropriate statistical tests. The results showed that siravedha is effective in the management of viswachi with special reference to cervical radiculopathy.

 INTIMATION FOR BODHIKA SEMINAR                                   15/11/2023

                 DEPARTMENT OF RASASASTRA AND BHAISHAJYAKALPANA

GOVT. AYURVEDA COLLEGE, THIRUVANANTHAPURAM

NAME  OF  FIRST PRESENTEE:Dr. DIVYA M V

DISSERTATION TITLE: REGENERATIVE POTENTIAL OF SWADAMSTRADI RASAYANA, AMALAKYADI RASAYANA AND THEIR INGREDIENTS IN ZEBRAFISH (Danio rerio)

NAME OF GUIDE:  DR.  RAJMOHAN V  MD (AY)

DATE:15/11/2023

TIME: 2:00-4:00 PM

VENUE: COLLEGE AUDITORIUM

                                                        ABSTRACT

Regeneration is a remarkable intrinsic capacity of the human body to restore damaged or lost tissues and functions, thereby maintaining homeostasis and overall health. At the level of the organism, the body has a propensity to go through and acquire changes throughout time, which are typically degenerative. Degeneration, often associated with the gradual deterioration of tissues and organs, is a natural consequence of ageing, and a range of genetic, environmental, and lifestyle factors can further exacerbate it. The intricate balance between degeneration and regeneration processes within the human body in biomedical sciences represents a multifaceted and critical study area. Regenerative medicine focuses on the functional restoration of specific tissues or organs in patients with catastrophic injuries or chronic disease states when their bodies natural regeneration processes fall short of what is required. Enriched with tailored approaches to health and disease, in addition to knowledge of distinctive practices using medicinal plants and peculiar dietary regiments, healthcare systems such as Ayurveda can provide a secure alternative to chronic and degenerative diseases and are increasingly used by individuals with such circumstances. Research opportunities for the biology of regeneration are made possible by the trophorestoration property of the medications and therapies indicated under Ayurvedic Rasayanatantra. Since, zebrafish fins make an excellent study tool for cellular and molecular mechanisms of regeneration, this study aimed to evaluate the regenerative potential of Swadamstradi Rasayana, Amalakyadi Rasayana and their ingredients in the amputated caudal fin of zebrafish. The experimental design was constituted by forty-nine fishes distributed into seven aquaria, receiving six treatments and the seventh one as the control group. Fishes from each treatment were anesthetized and had a portion of their caudal fin amputated with the intention to study the caudal fin's regeneration rates and period. Each experimental setup involved measuring each fish separately before and after amputation, followed by allowing the fish to grow while receiving treatment. To determine the regenerated portions, fishes of each group were subjected to image analysis on days 0, 3, 6, 9, 12 and 15

post amputation. The difference between the control group and the treatment exposed groups in the growth parameters such as caudal fin length increment and length gain percent were analysed. The statistical analysis of the experimental data revealed the variation in treatment means, which were then determined and statistically represented by repeated measures ANOVA, post hoc multiple comparison test (LSD) and independent sample t test. The result showed that the fishes in each treatment group reverted back to its pre amputated caudal fin length in shorter growth period compared to the control group (p<.01). The percentage mean caudal fin length increment was significantly different from control in Amalakyadi Rasayana and Amalaki (p<.05). The results of the study demonstrate the significant potential of two Rasayana yoga Amalakyadi Rasayana and Swadamstradi Rasayana, along with their constituent ingredients Amalaki, Tila, Swadamstra and Amruth, in promoting tissue regeneration in the amputated caudal fin of zebrafish. The knowledge could have implications for treating degenerative diseases in humans and could be applied to promote gene therapies or pharmaceutical interventions to promote regeneration

INTIMATION FOR BODHIKA SEMINAR                                   14/11/2023

                 DEPARTMENT OF RASASASTRA AND BHAISHAJYAKALPANA

GOVT. AYURVEDA COLLEGE, THIRUVANANTHAPURAM

NAME  OF  FIRST PRESENTEE:DR. SRUTHI  S S

DISSERTATION TITLE: ANALYTICAL PROFILING OF GUDUCHYADI KASHAYA AND REPEATED EXTRACTS OF ITS RETENTATE.

NAME OF GUIDE:  DR.  S .ANAND  MD (AY)

DATE:14/11/2023

TIME: 2:00-4:00 PM

VENUE: COLLEGE AUDITORIUM

                                                        ABSTRACT

Most of the Ayurvedic formulations are polyherbal in nature and phytoconstituents present in them are responsible for their therapeutic activities. But nowadays herbal drug pharmaceutical industries face many threats and challenges such as scarcity of raw drug materials, substitution and adulteration, reduction in quality, and increase in price of raw materials. Hence in this scenario, maximum utilisation of raw drugs should be ensured while preparing the Ayurvedic medicines for the preservation of biodiversity. The bioactive principles from herbal medicines are extracted with water, oil, ghee, milk, etc. but recovery of active principles into the extracted phase will not be complete. Therefore, the retentate or spent material of Ayurvedic formulations will be a very rich source of bioactive phytocompounds. This research study was conducted to determine the phytoconstituents retained in the spent material of Guduchyadi Kashaya. Physicochemical and phytochemical comparisons were done between Guduchyadi kashaya and subsequent kashayas prepared from its retentate. For this purpose, physicochemical analysis, chromatographic and spectroscopic techniques, mainly HPLC, LCMS/MS, NMR spectroscopy, TPC, and TFC analysis, were carried out in six samples of methanolic extract of lyophilized Guduchyadi Kashaya. As per the findings of this research study, phytoconstituents are retained in the subsequent kashayas prepared from the retentate of Guduchyadi Kashaya.The analysis using TPC, TFC, and LC-MS/MS showed that the concentration of certain phenolic and flavonoid compounds was increased in the subsequent kashayas. Statistically significant increase of berberine content in subsequent kashayas was observed in HPLC analysis. So, it can be concluded that retentate of Guduchyadi Kashaya contain phytoconstituents with significant therapeutic potential.