INTIMATION FOR BODHIKA SEMINAR - 10/08/2022

DEPARTMENT OF KAYA CHIKITSA

GOVT. AYURVEDA COLLEGE, THIRUVANANTHAPURAM

NAME  OF  FIRST PRESENTEE: Dr ANUPAMA  A S 

THESIS TITLE: EFFECT OF AMRITA GUGGULU AND 

RASNADASAMOOLA KWATHAM IN RHEUMATOID ARTHRITIS

NAME OF GUIDE: Dr PRAVITH N K 

DATE:10/08/2022

TIME: 2:00-4:00 PM

VENUE: HYBRID / MICROSOFT TEAMS 

ABSTRACT

Rheumatoid arthritis (RA) is a chronic inflammatory disease of unknown aetiology marked by a symmetric, peripheral polyarthritis. It is peaking between the ages of 35 and 50 and is a chronic disabling condition often causing pain and deformity. Clinically RA is similar to Vatarakta described in our classics. Vata prakopa and Rakta prakopa nidana leads to Raktavritha vata and lodges in Asthi sandhis. The clinical feature of Vatarakta is suggestive of deep dhathugata involvement. As it is an Avaranajanya Vyadhi, different preparations with drugs having Avaranaharatva, Vataanulomana and Rasayana properties are exclusively indicated in the management of Vatarakta. Amrita guggulu and Rasnadasamoola kwatham are two drugs having the above said qualities were selected as a combination to perform in its management.

The study was a before and after study without control group, conducted in Govt.Ayurveda College Hospital, Thiruvananthapuram. 20 patients fulfilling the inclusion and exclusion criteria diagnosed as Rheumatoid arthritis by satisfying the 2010 ACR-EULAR diagnostic criteria were selected and subjected to detailed clinical examination according to clinical research proforma and lab investigations. The study drug Amrita guggulu (500mg) twice daily with lukewarm water one hour after food and Rasnadasamoola kwatham (as sachet) with 60ml lukewarm water twice daily along with 6ml Eranda taila as anupana one hour before food  were given to the study participants for one month. Evaluation was done on 0^th and 31^st day. Statistical analysis reveals that there were significant reduction in subjective and objective parameters. Thus it is recommended that these drugs are effective and safe which can be used in the management of Rheumatoid arthritis.

NAME  OF  SECOND PRESENTEE: Dr VISHNUPRIYA L R

 

THESIS TITLE: 

EFFECT OF VYOSHADI GUGGULU IN 

NON-ALCOHOLIC FATTY LIVER DISEASE

  

NAME OF GUIDE: Dr K AMBIKA

NAME OF CO-GUIDE: Dr MINI V G

DATE:10/08/2022

TIME: 2:00-4:00 PM

VENUE: HYBRID / MICROSOFT TEAMS 

ABSTRACT

Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common chronic liver disease in many parts of the world. NAFLD represents a spectrum of disorders that have in common the presence of hepatic steatosis (fatty liver) in individuals who do not consume alcohol or do so in very small quantities (<20 g/day for women and <30 g/day for men). Diagnosis of NAFLD can be accomplished by history and physical examination, liver imaging and blood tests to exclude other liver diseases.

 

In Ayurveda various disorders of liver (yakrit) are described in detail, in different contexts. Mostly it is described under Pandu and Kamala rogas. A direct description regarding the fat metabolism and thus induced liver diseases are not seen in Ayurveda classics. From this we can infers that NAFLD may not be a common disease on the classical period due to various reasons. In later period, Bhavamisra in his work Bhavaprakasa explained liver disorders under Pleeha yakrit adhikara. It denotes the possibility of higher incidence of liver diseases later on, after Samhita period.

 

In NAFLD there is abnormal accumulation of fat in hepatocytes, drugs which have the property of deepana, pachana and kapha medohara are useful in the treatment. Vyoshadi guggulu is one such herbal formulation mentioned in Ashtangahridaya Vatavyadhi Chikitsa. The formulation is prepared according to the methods adopted from classical Ayurvedic textbooks in dose adjusted tablet form with date of administration  labelled in it for 90 days. An interventional pre – post study was conducted in the OP of Department of Kayachikitsa at Government Ayurveda College, Thiruvananthapuram. Patients are advised to take 2 tablets each weighing 500mg twice daily with lukewarm water as anupana. A total of 360 tablets, 120 in each visit in airtight packets were given to the patients. The periodical assessment was done on the 0^th and 91^st day. Statistical analysis showed that there was a significant change in Serum SGPT and slight change in fatty infiltration in USG without further progression during the study period. No drug reactions were noted during the study period. The study was concluded to be effective in reducing the Serum SGPT level and preventing further progression in grading of fatty liver.