INTIMATION FOR BODHIKA SEMINAR - 31/08/2022

*BODHIKA SEMINAR FOR 31/08/2022 WILL CONDUCT THREE PRESENTATIONS, 2 FROM THE DEPT OF R&B AND 1 FROM THE DEPT OF SHALYA TANTRA*

DEPARTMENT OF RASA SHASTRA & BHAISHAJYA KALPANA

GOVT. AYURVEDA COLLEGE, THIRUVANANTHAPURAM

NAME  OF  FIRST PRESENTEE: Dr RESMI BABU

THESIS TITLE:MICROBIAL STABILITY OF 

NAYOPAYAM PRAVAHI KWATHA

NAME OF GUIDE: Dr S THARALAKSHMI

DATE:31/08/2022

TIME: 2:00-4:00 PM

VENUE: COLLEGE AUDITORIUM

ABSTRACT

 Pancha vidha Kashaya kalpanas are five basic preparations of Bhaishajya kalpana.and which includes swarasa, kalka, kwatha, hima and phanta.Among them kwatha Kalpana is most significant and widely used dosage form. This is prepared by boiling of herbal drugs with water in a specific proportion .Pravahi kwatha is concentrated kashaya.It is obtained by boiling the ingredients of a specified kwatha churna formulation in a given amount of jala (API part 2 volumes 4).Addition of preservatives in pravahi kwatha is permitted as per API. Nayopayam pravahi kwatha is a decoction prepared with bala, jiraka, shunti in a ratio 10:2:2 (API Part 2 volume 4).Kwatha Kalpana has more chance to get contaminated with microbes as it is an aqueous preparation. Also during boiling of kwatha starch from drugs gets dissolved. Which provides media for the growth of micro organisms leading to its decomposition. Preservatives are used to prevent microbial contamination. As per the thesis “a study on the type and concentration of preservatives used in kwathas by the leading GMP certified companies in kerala” done in Govt. Ayurveda College, Trivandrum, it was noted that the amount of preservatives in kwatha preparation is 10 times more than the permitted limit. So, through a long-term shelf life study, an attempt was made to detect the microbial stability of Nayopayam Pravahi Kwatha with the permitted amount of preservatives using parameters such as microbial contamination, colour, odour, taste, moisture content, pH, specific gravity, and total solid content. An online survey was conducted among the GMP certified companies in kerala preparing concentrated kashayas to collect the details of preservatives in pravahi kwatha. 

NAME  OF  SECOND PRESENTEE: Dr SANDHYA S R CHANDRAN

THESIS TITLE: IN-VITRO ANTI-INFLAMMATORY

 ACTIVITY OF PACHANAMRUTHAM KASHAYAM

NAME OF GUIDE: Dr S THARALAKSHMI

DATE:31/08/2022

TIME: 2:00-4:00 PM

VENUE: COLLEGE AUDITORIUM

ABSTRACT

Inflammation is generally referred to as a complex biological response of vascular tissues to harmful stimuli such as pathogens damaged cells or irritants¹. But in some occasions, the body is not able to regulate the inflammatory response. This results in chronic imbalance and chronic pain. Ayurveda has a wide spectrum of therapeutic preparations for inflammation and many people depend on ayurvedic treatments. Pachanamrutham kashayam is a kashaya yoga used by traditional ayurvedic physicians since past due to its efficacy in the management of jwaram, aamam and all other inflammatory conditions. The source of this kashaya yogam is Sahasrayogam. Its anti-inflammatory property is not scientifically validated yet. Since cell lines are the basic level of evidence, an in vitro study need to be conducted to prove the same. For this Pachanamrutham kashayam was prepared and its anti-inflammatory activity assay was conducted in RAW 264.7 cells by testing the Cyclo-oxygenase (COX) Activity, Lipoxygenase (LOX) Activity, Myelo Peroxidase Activity, Cellular nitrite levels and iNOS synthasase level. The percentage of inhibition of diclofenac sodium and Pachanamrutham kashayam in three different concentration 25, 50, 100(µg/ml) was calculated. LPS stimulated cells were taken as control group. Statistical analysis of the results were done .From the results, it may be concluded that the polyherbal decoction Pachanamruthamkashayam significantly reduces the inflammation by inhibiting the inflammatory  processes(p<0.001) . The diclofenac sodium has more inhibitory effects on inflammation in the same concentration of kashayam . IC 50 values of the kashayam and diclofenac sodium was calculated which gives us a primary idea as to calculate on the dose and frequency of Pachanamritamkashayam to get comparable or better results to dichlorofenac Sodium.

*3rd PRESENTATION FROM DEPT OF SHALYA TANTRA *

NAME  OF  THIRD PRESENTEE: Dr ASWATHI NAIR V

THESIS TITLE:EFFECT OF SELECTED TREATMENT 

PROTOCOL IN THE MANAGEMENT OF AVASCULAR 

NECROSIS OF HEAD OF FEMUR.

NAME OF GUIDE: Dr M S DEEPA

NAME OF CO-GUIDE: Dr REMYA V R

DATE:31/08/2022

TIME: 2:00-4:00 PM

VENUE: COLLEGE AUDITORIUM

ABSTRACT

Avascular necrosis of head of femur is a common condition in orthopedic practice. It

is basically an osteonecrosis caused due to an injury or any occlusion in the blood vessels nourishing the bone tissue. AVN of the femoral head is the most common type of necrosis because the artery supplying to that area is very narrow which easily gets injured followed by mere dislocation or a sub capital fracture which leads to lack of nourishment resulting in necrosis¹. In modern medicine, no any specific treatment rather than surgery is available.Moreover it is expensive and has poor prognosis too. In Ayurveda, it can be considered as asthikshaya. Ayurvedic treatment is more cost effective and have no side effects. Also a well- documented scientific validation will certainly pave the way for main streaming of Ayurvedic management in this condition.

The aim of the study was to evaluate the effect of an Ayurvedic treatment protocol in the management of avascular necrosis of head of femur. Study design was formulated as interventional pre and post study without control. Sampling method was consecutive sampling and the sample size was 10. Participants of both sex registered in Govt. Ayurveda Hospital Thiruvananthapuram in the age group 20-50 years diagnosed with AVN of head of femur as per the inclusion and exclusion criteria were selected for the study. The participants were subjected to bandhana and application of murivenna, rookshasweda with kolakulathadi churna, snehapana with gugguluthikthaka ghrita, abhyangam with ketakimooladi taila, virechanam with nimbamriteranda taila, kayasekam with dhanwantaram taila and finally panchathikthaka ksheeravasti. Amritotharam kashayam and vaiswanaram churnam were given internally in the first stage of the treatment. In the next stage, ie, after snehapana, it was changed to rasnerandadikashayam and tab yogarajaguggulu. Assessment had done before and after the treatment and after follow up period. ie, after 3 months. Data was analyzed according to Paired t test. And the result was found to be statistically significant.