INTIMATION FOR BODHIKA SEMINAR - 7/2/2022
NAME OF FIRST PRESENTEE :DR APARNA S G NAME OF GUIDE: DR A SHAHUL HAMEED
DATE: 07/02/2022
TIME: 2:00-4:00 PM
VENUE: MICROSOFT TEAMS
ABSTRACT
Cosmostigma racemosum(Roxb.)Wight is a green milky weed climber belonging to Asclepiadaceae family. The present study is conducted to evaluate the wound healing activity of the plant. The descriptions from Hortus Malabaricus and various ethnobotanical studies of the sacred groves of temples in Kannur district serve as the base of this study. Wound healing is a complex process, which involves haemostasis, inflammation, proliferation and remodelling with scar tissue formation. The mobilization and proliferation of fibroblasts and angiogenesis play a major role in wound healing. A potent wound healer aids the body tissues in these steps more effectively by reducing the healing time .
The pharmacognostical, physical and phytochemical analysis of Cosmostigma racemosum(Roxb.) Wight are done as these details are not yet scientifically validated. In the in vitro assay, the cell mobilization of fibroblasts will be monitored by Scratch assay of L929 cells. Angiogenetic potential of the drug will be assessed using CAM Assay model (Chick Chorioallantropic membrane model). The wound healing activity of the plant is studied in vivo in Wistar rats by Excision wound model. Excision wounds of approximately 450mm2 will be made on the dorsal side of pre anesthetised rats. Three groups containing six rats each are used for study. For group I topical serveas the negative control.For group II application of Povidone iodine is used which serve as the standard. For Group III topical application of leaf paste of Cosmostigma racemosum (Roxb.)Wight is used which serve as the test group. The application is once daily for 14 days. Assessment will be done on 0th , 2nd ,4th ,6th ,8th ,10th and 14th days. The rate of wound contraction, period of epithelisation and histopathological analysis are assessed by this model.
NAME OF GUIDE: DR M S DEEPA
DATE: 07/02/2022
TIME:2:00-4:00 PM
VENUE: MICROSOFT TEAMS
ABSTRACT
Metabolic syndrome (MS) states to a
constellation of various interrelated cardio metabolic risk factor that promote the development of atherosclerotic
cardiovascular disease (CVD) and Type
2 diabetes mellitus (T2DM). The major components of the syndrome include
insulin resistance, abdominal
obesity, atherogenic dyslipidaemia, elevated blood pressure. Insulin resistance is considered as a commonly
accepted amalgamating theory explaining the pathophysiology
of MS. Prevalence of MS has increased considerably reaching pandemic proportions worldwide.[3] IDF estimates
that approximately 25% of world population have MS. Though a direct correlation of MS is unavailable in
Ayurveda, it can be stated under the broad
umbrella of santarpanajanya vyadhi.
From the etiology and symptomatology it can be
inferred that MS involves a kapha
pradhana tridosha dushti, with meda being
the prime dushya.
The drug Kakamachi (Solanum nigrum Linn) is katu- tikta rasa, ushna veerya, and katu vipaka and tridoshagni (pacifies tridoshas). It is, hrdhya, (Cardiotonic) rasayana(rejuavanative), hrdrogavinasana (beneficial in curing heart disease)and mehajith (antidiabetic) yakrtuttejaka (hepatoprotective) Its hypoglycemic, dyslypidemic, hepatoprotective, cardioprotective and anti-inflammatory effects are already proven experimentally.
It is an interventional study. Both male and female, in the age group of 25-65 years, having harmonized criteria of metabolic syndrome, attending Government Ayurveda College Hospital, Out Patient Department (GAVC OPD) will be randomly allocated to either experimental or control group. The study drug, whole plant of kakamachi is dried in sunlight and powdered .Then it will be made into 500 mg capsules were given to patients of experimental group .The control group will be given similar 500 mg capsule of placebo drug. The subjects of both the group will be advised to take 2 capsules each twice daily before food for a period of 90 days. All the subjects in both the groups continuously received their medication. Study tool is laboratory investigations (HOMA – IR, FBS, SBP, DBP, S.TG, and S.HDL). All these parameters will be analysed.
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