INTIMATION FOR BODHIKA SEMINAR - 18/01/2023
DEPARTMENT OF DRAVYAGUNAVIGYANA
NEPHROPROTECTIVE EFFECT OF ARDHAVILWA YOGAM AGAINST GENTAMICIN INDUCED NEPHROTOXICITY IN ALBINO RATS
NAME OF GUIDE: Dr A. Shahul Hameed
TIME: 2:00-4:00 PM
VENUE: COLLEGE AUDITORIUM
ABSTRACT
Chronic diseases have become a major cause of global morbidity and mortality. The increasing prevalence of chronic kidney disease (CKD) progressing to an end-stage renal disease and the consequent financial burden of renal replacement therapy has become a major problem in society. As there is lack of effective nephroprotective drugs in modern medicine, there is a scope of validating traditional medicine especially Ayurvedic drugs with nephroprotective potential. Ardhavilwa yogam an indigenous herbal formulation quoted in Sahasrayogam is a promising drug combination with possible nephroprotective effect. Ardhavilwa yogam contains Chukku: Sanskrit - Sunthi (Zingiber officinale),Chunda:Sanskrit -Brihati (Solanum torvum) , Kadaladi: Sanskrit -Apamarga ( Achyranthes apsera ) , Kodituva : Sanskrit –Dusparsha (Tragia involucrate) and Tazhutama : Sanskrit-Punarnava (Boerhaavia diffusa ). It is indicated in sopha, a condition characterized by generalized edema. As generalized edema is major sign of renal failure mainly due to nephrotic syndrome this formulation may have positive benefits. Moreover some studies have proved the nephroprotective effects of ingredients of this formulation, but the synergetic effect is not yet proven.
The nephroprotective activity of formulation Ardhavilwa yogam will be studied in gentamicin induced nephrotoxicity in male Albino rats. Six groups of rats ,six in each group is taken for the study.Group 1will be normal control group, group 2 given gentamicin only ,group 3 given silymarin as standard drug along with gentamicin, group 4& 5 will be given the study drug Ardhavilwa yogam in decoction form in effective and double dose along with gentamicin, &group 6 will be given hydro alcoholic extract of study drug with gentamicin for 8 days. The gentamicin injection will be given as i.p after one hour of drug administration and animals are kept in metabolic cage. On 9th day the animals will be sacrificed and nephroprotective effect of Ardhavilwa yogam will be evaluated by histological examinations and biochemical analysis of kidney functions. Anti -oxidant activity of the formulation will be determined by in vitro methods . Results will be statistically analysed by ANOVA.
TIME: 2:00-4:00 PM
VENUE: COLLEGE AUDITORIUM
ABSTRACT
Liver is the largest solid organ in the body which plays a crucial role in digestion and metabolism of proteins, carbohydrates and lipids. It is responsible for the metabolism of drugs and toxins. The diseases of liver are a major cause for morbidity and mortality worldwide. Liver diseases accounts for approximately two million deaths per year worldwide, one million due to complications of cirrhosis and one million due to viral hepatitis and hepatocellular carcinoma. Despite the tremendous strides in modern medicine, there is hardly any drug that stimulates liver functions or offer protection to liver damage or helps in regeneration of hepatic cells
The liver disorders are seen in Ayurveda mainly through the window of Kamala. The detailed description of Kamala, its clinical features and management is available in almost all the Ayurvedic textbooks. Sahadevyadi yogam is a polyherbal formulation from Vaidyamanorama , told in the context of Kamala. It is a combination of three herbs viz. Sahadevi (Vernonia cinerea) , Ajjata (Phyllanthus amarus) and Pathya (Terminalia chebula).
Individually, single plant extract has been reported to have hepatoprotective activity. However there is no sufficient scientific data published on pharmacological evaluation of these plants in combined form which results in synergistic effect. So the present study aims to investigate the protective effect of Sahadevyadi yogam against Paracetamol induced hepatotoxicity in Albino rats. Six groups containing 6 rats are used for the study. Group I serves as normal control, Group II receiving Paracetamol, Group III receiving the standard drug Silymarin ,Group IV and V internal administration of Sahadevyadi yogam in therapeutic dose and double the therapeutic dose, Group VI receiving hydroalcoholic extract of the formulation . Hepatotoxicity will be induced by administering Paracetamol. After 24 hours of administration of Paracetamol, the animals will be euthanized. Effect will be assessed by doing biochemical analysis and histopathology. Acute toxicity study will be done as per OECD guidelines 425.Antioxidant activity of the formulation will be determined by invitro methods. The results will be statistically analysed by ANOVA
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