INTIMATION FOR BODHIKA SEMINAR                                       10/05/2023

                                          DEPARTMENT OF DRAVYAGUNAVIJNANIYA

GOVT. AYURVEDA COLLEGE, THIRUVANANTHAPURAM

NAME  OF  FIRST PRESENTEE: Dr.SENHA N

DISSERTATION TITLE: Efficacy of ‘Nimbadi yogam’ as an-add on medication in Type 2 Diabetes mellitus subjects on Metformin monotherapy – a randomized controlled trial.

NAME OF GUIDE:  Dr. M.S Deepa MD (Ay)

DATE:10/05/2023

TIME: 2:00-4:00 PM

VENUE: COLLEGE AUDITORIUM

                                                                         ABSTRACT

Diabetes mellitus is a metabolic disorder resulting from a defect in insulin secretion, insulin action, or both. Insulin deficiency in turn leads to chronic hyperglycemia with disturbances of carbohydrate, fat and protein metabolism. There are two main types of diabetes, type 1 (requiring insulin for survival) and type 2 (may or may not require insulin for metabolic control). Diabetes is a major health issue that has reached alarming levels today and nearly half a billion people are living with diabetes worldwide. The prevalence of Diabetes in India is 8.9%. Kerala is the diabetic capital of India with a prevalence of diabetes as high as 20% i.e. more than double the national average. Diabetes can be correlated with Prameha in Ayurveda, there are many formulations mentioned in Ayurvedic classics and they are found to have significant hypoglycemic effect. The study drug is a polyherbal formulation containing Nimba ,Ushira , Amalaki  and Haritaki, mentioned in one of the classical ayurveda texts chakradutta in the chapter of treatment of prameha. The objective of the study is to evaluate the hypoglycemic effect of Nimbadi yogam as an add-on medication in type 2 diabetes mellitus patients with inadequate glycemic control on conventional oral hypoglycemic agent Metformin alone. The study is interventional type. Both male and female subjects of age group 25-70 years with FBS level from 126-180 mg/dl, PPBS level from 200-250 mg/dl ,HbA1c level from 6.5%- 8.5% and taking Metformin monotherapy, attending OPD of Govt. Ayurveda College, Thiruvananthapuram were selected for the study. Subjects with major systemic illness and complications were excluded. The study population was divided into two groups as experimental and control groups. In this study Nimbadi yogam was dispensed in a potentiated form in which choorna of four drugs will be powdered and potentiated in the decoction of these four drugs and the resultant powder was made into 500 mg tablets. The tablet was dispensed to the subjects of experimental group along with nishakadakadhi tarpana kwatha and the control group was administered Nisakathakadi tarpana kwatha alone. The subjects of experimental group was advised to take 2 tablets thrice daily before food along with Nisakathakadi tarpana kwatha for a period of 90 days with the stable dose of Metformin. The required laboratory investigations were done before and after the study period. The study is ongoing and the collected data will be subjected to statistical analysis using appropriate statistical techniques. Results will be drawn, summarized and conclusions will be made.

NAME  OF  SECOND PRESENTEE: Dr.ASWATHI A

DISSERTATION TITLE: Effectiveness of Karkasadaladi yogam in Dyslipidemia

NAME OF GUIDE:  Dr. Indulekha V C

DATE:10/05/2023

TIME: 2:00-4:00 PM

VENUE: COLLEGE AUDITORIUM

                                                                         ABSTRACT

According to the World Health Organization (WHO) estimates in 2008, the prevalence of dyslipidemia (defined as blood levels of TC 190 mg/dL) in the Southeast Asia is 30.3%, in Europe 53.7% and in America 47.7%. The prevalence of dyslipidemia is very high in India also according to ICMR–INDIAB Study; 13.9% had hypercholesterolemia, 29.5% had hypertriglyceridemia, 72.3% had low HDL-C, 11.8% had high LDL-C levels and 79% had abnormalities in one of the lipid parameters. It is a common significant risk factor for dyslipidemia included obesity, diabetes, and dysglycemia and needs for urgent lifestyle intervention strategies to prevent and manage this important cardiovascular risk factor.

Dyslipidemia, including high levels of total cholesterol, low-density lipoprotein cholesterol, and triglyceride, and low levels of high-density lipoprotein cholesterol, is a major risk factor of atherosclerosis that leads to various cardiovascular diseases .

Therefore, early screening and effective lipid management may substantially reduce the burden of CVD and provide great social value.

Ayurvedic medicines and food products are widely used for management of dyslipidemia in India. The karkasadaladi yogam is a formulation described in Bhavaprakasa in Medoroga (dyslipidemia and obesity) chapter; which is a combination of karkasadala(Trichosanthes cucumerina Linn), Chithraka(Plumbago rosea), Hingu(Ferula asafoetida) and sathapushpa (Anethum graveolance).

Method

Karkasadaladi yogam will be prepared as choorna (powder) of karkasadala and Chithraka and Hingu and sathapushpa potentiated with Kashaya of karkasadala and Chithraka and will be packed as 500 mg tablet.  To evaluate the effect of Karkasadaladi yogam in dyslipidemia, it will be given as 2 tablet (each of 500mg) twice daily after food for 3 months. The patients will be taken from the OPD of Govt. Ayurveda college hospital, Thiruvananthapuram, both sexes, aged 25 to 60 years and having Hypercholesterolemia is defined as TC >200mg/dl, LDL-C as >130mg/dl, hypertriglyceridemia as TG >150mg/dl HDL-C below 40.   The efficacy of Karkasadaladi yogam will be assessed by comparing LDL-C, TC and triglycerides values before drug administration and after 90 days of drug administration; and the data will be statistically analysed. Blood samples will be collected on 8 hours fasting at baseline and 91^st day.

 Statistical analysis plan.

            Mean values of serum HDL, LDL, and Triglycerides of drug treated subjects at baseline and 91^st day   will be analysed with paired t test; if the values follow normal distribution.