INTIMATION FOR BODHIKA SEMINAR 

                              3/7/2024

                        DEPARTMENT OF KAYACHIKITSA

FIRST PRESENTEE :  Dr. ASWATHY DEV S

DISSERTATION TITLE  : EFFECT OF AVIPATHIKARA CHURNA WITH SHANKHA BHASMA AND SHARIBADI PANAM IN AMLAPITHA

Name of Guide    :   Dr. Sunil John Thykkattil                                                                

DATE                  :   3/7/2024

Time                    :      2 pm

Venue                  :    college auditorium

                                                             ABSTRACT

The disease Amlapitha is vividly described in different classical texts of Ayurveda like Kasyapa Samhita and Madhava Nidana. As per classics Amlapitha can be defined as a condition where already accumulated pitha in the body gets further aggravated by consuming virudha dushta vidagdha aharas that is incompatible food combinations, putrified foods, overburnt foods and drinks. The main clinical features of Amlapitha include avipaka, klama, utklesha, thikthamlodgara, hritkantadaha, guruta and aruchi. Excessive formation of vitiated pitha is the main pathological mechanism behind the manifestation of this disease. It is a pithavikruta annavaha srotovikara associated with vitiation of kledaka kapha. Here pithavikruti increases the quantity of dravarupa pachaka pitha and affects the quality of kledaka kapha. Symptomatically modern correlation of Amlapitha appears most similar to Functional Dyspepsia. Dyspepsia is a symptom complex connected to the gastro-duodenal region of gastrointestinal tract and includes postprandial fullness, early satiety, epigastric burning vomiting, nausea which has a significant impact on health. More than 50% of patients are on medications most of the time and have significantly reduced quality of life in comparison with the general population. Functional dyspepsia is a common ailment with possible causative factors being the change in lifestyle and food habits. Patients with functional dyspepsia account for about 80 percent of cases and have no structural explanation for the same. Even though pathophysiology cannot be accurately explained, studies point to disordered communication between gut and brain leading to motility disturbances visceral hypersensitivity and alteration in visceral microbiota mucosal and CNS processing. Psychological factors and stress are found to be aggravating factors and are attributed to pitta dosha. In amlapitta pitta and kapha are the key factors in pathology. This study is being undertaken in an effort to find an effective combination of medicines in the management.  It includes administration of Avipattikara churna with shankha bhasma and sharibadi panaka for 21 days. A   follow up of these patients is also done. Results of the study showed significant reduction in symptoms. Chi square value for comparing the effect of intervention on total score at different time periods was found to be significant and P value was less than 0.001. At 1% level of significance, there is a significant difference in total scores. It suggests that treatment can lessen the severity of the illness.

SECOND PRESENTEE : Dr AMBILY K ASHOK

DISSERTATION TITLE  : EFFECT OF SELECTED AYURVEDIC TREATMENT MODALITIES ALONG WITH SLEEP HYGIENE EDUCATION IN PRIMARY INSOMNIA

Name of Guide    :   Dr Suneeshmon M.S MD (Ay                                                          

DATE                  :   3/7/2024

Time                    :      2.30 pm

Venue                  :    college auditorium

                                                                    ABSTRACT

Sleep, a physiological state of rest during which volition and consciousness are in partial or complete abeyance, plays a recuperative and adaptive function in human lives. Quality sleep acts as rejuvenator, enabling us to function at our zenith during working hours where deprivation of the same causes a lot of neurophysiological derailment in the body.

Insomnia is in fact, both a symptom as well as a disorder. If left untreated, insomnia increases the risk of developing diseases like depression, diabetes, hypertension and possibly even death in older individuals as per reported studies¹. Therefore it is very much essential to identify and treat the condition of insomnia at the earliest. ‘Sleep hygiene’ is the term used to describe good sleep habits.Considerable research has gone into developing a set of guidelines designed to enhance good sleeping, and there is much evidence to suggest that sleep hygiene are fairly inexpensive but much effective intervention. There are many medications used to treat insomnia, but these lead to dependence and interfere with one’s day to day activites, thereby prolonging sleep difficulties².

In Ayurveda, Nidra is one among the Trayopasthambha. Nidranasha is a nanatmaja vikara mentioned by Charaka³. Principle dosas involved are vata and pitta. Study to be carried out may be helpful in the management of Primary Insomnia in patients attending Kayachikitsa OPD and IPD Govt Ayurveda College Hospital Thiruvananthapuram. It is interventional pre and post single group with sample size of 20 participants fulfilling the inclusion and exclusion criteria diagnosed as primary insomnia as per ICD11 criteria will be selected and subjected to detailed clinical examination according to clinical research proforma. The intervention includes trina panchamoola ksheera shirodhara for 45 minutes for a duration of 7 days followed by internal administration of Sankhupushpi choornam capsules for a duration of 14 days along with sleep hygiene. Quality and quantity of the sleep will be assessed. Proper evaluation before and after the intervention will be adhered to and follow-up will be done at the end of study. The results obtained will be statiscally analysed and concluded.

Keyword : Primary insomnia , Nidranasa, Trinapanchamoola ksheera sirodhara, Sankhupushpi choornam capsule

NAME OF THIRD PRESENTEE : DR.KAVYA A.G

DISSERTATION TITLE  : 

EFFECT OF local Dhanyamla DHARA  and aqueous extract of SUNDIBALADWAYA   KWATHA with ksheerabala 7 avarthi In DIABETIc peripheral NEUROPATHy

Name of Guide    :   Dr PRAVITH N.K                                                       

DATE                  :   3/7/2024

Time                    :   3 pm

Venue                  :    college auditorium

                                                                            ABSTRACT

Diabetic neuropathy (DN) refers to the presence of symptoms or signs of peripheral nerve dysfunction in people with diabetes mellitus after exclusion of other causes. Distal symmetrical neuropathy is the commonest, accounting for 75%  of DN. Over a period of time, the nerves gets affected, especially the peripheral nerves leading to Diabetic Peripheral Neuropathy (DPN). DPN being a progressive complication phase of diabetes can be understood as Vata pitta predominant thridosha stage with concepts of Avarana, causing dhathukshaya .   The drugs used conventionally are mostly for relief in the symptoms and moreover a large population of patients began to  choose  among  alternative medicinal options, there comes the need for more research in Ayurveda medicines too.

 

According to Ayurveda classics, there is no direct nomenclature for DPN , but can be treated  under the spectrum of prameha upadrava involving thridosha dushti and dasa dathu dusthi. Diagnosis of DPN is done by Nerve Stimulation study and Toronto Clinical Neuropathy Score. Effect of sundibaladwaya kwatha with ksheerabala 7 avarthi anupana is a previous study conducted in GAVC, TVM by Dr. Arunitha during 2017 which was found to be effective in DN, with a P value of 0.001 . In this study, along with the previous study drug , an external intervention of dhara with dhanyamla is  also included to assess the effect. Dhanyamla is dahasamana, sparsa seethala and vatha kapha samana. When administered as a Dhara procedure, it  facilitates  vasodilation as well as nerve stimulation and  helps in reducing occlusion,  thereby correcting the pathology of Diabetic Peripheral Neuropathy As a disease of chronic origin and deep seated pathology,Vatha predominant thridosha dushti may be considered ,for the symptoms of numbness and parasthesia Vatha- Kapha dushti and for symptoms like burning sensation, Pitha dushti can be accounted.Thus this intervention helps in samana of prakupitha vatha along with pacifying vitiated pitha and kapha.

Key words: Diabetic peripheral neuropathy,Suntibaladwayakwatham,dhanyamla dhara

INTIMATION FOR BODHIKA SEMINAR 

                                26/6/2024

                        DEPARTMENT OF KAUMARABHRITYA

FIRST PRESENTEE :  Dr. ANJANA CHANDRAN K

DISSERTATION TITLE  : COMBINED EFFECT OF THRIKATUKADI MODAKA AND UDWARTHANA WITH THRIPHALA CHURNA ALONG WITH PRESCRIBED DIET IN THE MANAGEMENT OF EXOGENOUS OBESITY IN CHILDREN OF AGE GROUP 6 TO 12 YEARS.

Name of Guide    :   Dr LEKSHMI MK                                                                 

DATE                  :   26/6/2024

Time                    :      2 pm

Venue                  :    college auditorium

                                                                         ABSTRACT

Body mass index greater than or equal to the 95th percentile for age and gender in children aged two years and older is called obesity. Exogenous obesity caused by a caloric intake greater than the need to meet the metabolic needs of the body. More than 39 million children are obese all over the world. In India 12.1% of males, 16% of females and 11.7% children are obese. Obesity decreases the quality of life both in childhood and adulthood. Children are prone to become obese due to the predominance of Kapha. Kapha and Medas play major role in the samprapthi of obesity. The interventional drug Thrikatukadimodaka possesses katu tiktha rasa, ruksha theekshna guna  and ushna veerya. Thriphala churna which has medohara property is used for udwarthana. Both helped in samprapthivighatana of exogenous obesity. The study is going on in the OPD of Govt. Ayurveda College Hospital for Women and Children, Poojappura, as a clinical trial with pre, post and post-follow up assessment. Children of both sex with signs and symptoms of obesity coming under the age of 6-12 years attending O P of Kaumarabhritya will be selected for the initial screening which includes case taking along with assessment for obesity using the parameters BMI, Weight, Mid arm circumference, Hip circumference, Abdominal circumference and Mid -thigh circumference. Trial group will receive medicines and procedure along with prescribed diet for a period of two months. Follow up will be done after one month. Data will be collected and statistically analysed using Repeated measures Anova.

Key words: Exogenous obesity, BMI, Thrikatukadi modaka, Thriphala churna, Udwarthana

SECOND PRESENTEE : Dr.ANUPAMA S

DISSERTATION TITLE : COMBINED EFFECT OF DHATRI PAYASYADI GHRITHA ALONG WITH DIETARY ADVICE IN UNDERNOURISHED CHILDREN OF AGE GROUP 3-6 YEARS.

 Name of Guide  :   Dr.SOHINI S                                                                

DATE                  :   26/6/2024

Time                    :      2 .30 pm

Venue                  :    college auditorium

                                                             ABSTRACT

Nutrition plays an important role in the physical, mental and emotional development of children. Undernutrition is widely recognised as a major health problem in developing countries of the world. It is a condition in which there is inadequate consumption, poor absorption or excessive loss of nutrients. It is defined as being underweight for one’s age, too short for one’s age (stunting), dangerously thin for one’s height(wasting), and deficient in vitamin and minerals (micronutrients) as an outcome of insufficient food intake, inadequate care and infectious diseases. It affects more than one third of world’s children making it the most damaging form of malnutrition worldwide. It has critical consequences for physical and cognitive growth and development in children. According to NFHS – 5 survey, 32.1% were having underweight and around 45% of deaths among children under 5 years of age are linked to undernutrition.

Ayurveda is mainly based on preventive aspect first rather than curative. It explains the disease ‘Karshya’ which can be taken as the nutritional deficiency disorder where weight loss (underweight) is the main feature. 

A clinical study was designed to evaluate the combined effect of Dhatripayasyadi Gritha along with dietary advice in undernourished children of age group 3 to 6 years. The study was conducted as an interventional, pre and post-test. It was carried out in OP Department of Kaumarabhritya, Govt. Ayurveda College Hospital for Women & Children, Thiruvananthapuram. Children of both sex satisfying the inclusion criteria of weight for age less than 2 standard deviation from median reference according to National Centre for Health Statistics (NCHS) was included in the study, screened and assessed using case proforma and anthropometric measurements. Then the trial drug Dhatripayasyadi Gritha was given in a dose of 3.5ml twice daily with lukewarm water as anupana along with proper dietary advice for a period of 2 months with follow up of 1 month. Weight, BMI, mid upper arm circumference, chest circumference and clinical parameters grading were done before treatment, after treatment and after follow up. Data will be collected and statistically analysed using Paired t test and Wilcoxon sign rank test.

Keywords : Dhatripayasyadi Ghrita, Karshya, Undernutrition, Weight.

NAME OF THIRD PRESENTEE : Dr.LAKSHMI N MENON

DISSERTATION TITLE : EFFECT  OF BHARNGYADI KASHAYA AS ARKA IN BRONCHITIS AMONG CHILDREN OF THE AGE GROUP 3-10 YEARS

 Name of Guide  :   Dr. ANILKUMAR M V                                                             

DATE                  :   26/6/2024

Time                    :      3 pm

Venue                  :    college auditorium

                                                              ABSTRACT

Bronchitis is a condition in which the airways in the lungs, called bronchial tubes, become inflamed and cause coughing, often with mucus. Bronchitis can be acute (short-term) or chronic (long-term).Acute bronchitis is an acute respiratory infection that is manifested by cough and at times, sputum production that lasts for no more than 3 weeks. Viral infections, such as the cold or flu, are usually the cause, and most people recover after a few days or weeks. Occasionally, acute bronchitis can be caused by a bacterial infection. Chronic bronchitis is defined as a productive cough that lasts at least three months, with recurring bouts occurring for at least two consecutive years. Signs and symptoms of both acute and chronic bronchitis include, persistent cough, which may produce mucus, wheezing, low fever and chills, feeling of tightness in the chest, sore throat, body aches, breathlessness, headache and blocked nose and sinuses.

A clinical study is designed to evaluate the effect of Bharngyadi Kashaya as Arka in Bronchitis among children of the age group 3-10 years. The formulation Bharngyadi Kashaya is explained in Jwararoga adhikara of Sahasrayoga- by M Narayana Vaidyar, Edakkad. It is prepared as per Arka Kalpana. Arka prakasa of Ravana, opines that it has more potency in comparison to the other kalpanas. Moreover, due to its increased potency, reduced dose, better shelf life, easy absorption, fast action and patient compliance, it would be the best choice among paediatric population.

The study will be conducted as an interventional pre and post-test. Children of both sex of age group 3-10 years satisfying the inclusion criteria will be selected for the study. The trial drug, Bharngyadi Kashaya as Arka will be administered for a period of 21 days in a dose of 5ml to children of 3-5 years and 10 ml for 6-10 years with equal amount of lukewarm water. All children in the study will be assessed each week using subjective symptomatic grading of clinical features by using Bronchitis Severity Score (BSS), PEFR and oxygen saturation. The blood parameters (TC, DC, ESR, AEC) will be assessed before and after the interventional period. The data collected will be analysed statistically using Wilcoxon signed rank test or Paired t test depending on the pattern of distribution.

KeKeywords: Bronchitis, Bharngyadi Kashaya, Arka, Bronchitis Severity Score.

  INTIMATION FOR BODHIKA SEMINAR 

                               19/6/2024

DEPARTMENT OF DRAVYAGUNAVIGYAN

NAME OF FIRST PRESENTEE :  Dr. SHILPA V

DISSERTATION TITLE : Hepatoprotective effect of Borassus flabellifer Linn on Paracetamol induced hepatotoxicity in Albino rats

Name of Guide     :   Dr A Shahul Hameed                                                                    

DATE                   :   19/6/2024

Time                   :      2 pm

Venue                 :    college auditorium 

                                                                      ABSTRACT

Liver is the principal site of metabolism, detoxification and elimination of toxic substances and it is involved in most of the biochemical pathways to combat disease, supply nutrient and energy to the cell. In the modern era, human beings are exposed to multiple chemicals that may cause injury to liver cells and impair the  function. Liver offers the first line of protection against damage by ingested agents and therefore, it is very important to protect the liver. Drug-induced hepatotoxicity is one of the challenging clinical problems that account for 13% of all cases of the acute liver failure. Ayurveda term for Liver is Yakrut and the diseases affecting it are classified under Yakrut and Pleeha (spleen) rogas. Since both Yakrut and Pleeha are the basic organs of Rakthavaha srotas and as they are having the same embryological origin and the etiology, classification and treatment of diseases, affecting both are on the same line. There are many Ayurveda drugs which are indicated in the pathological conditions of Liver. The male inflorescence of Borassus flabellifer Linn is one among them. The male inflorescence of Borassus flabellifer Linn is called Talapushpa in Sanskrit and Panaviral in Malayalam. Talapushpa kshara along with Guda is mentioned in Yakrut-pleeha adhikarana of Chakradatta. But this claim has not been validated till now. Hence this study was taken up to validate the hepatoprotective effect of the male inflorescence of Borassus flabellifer Linn on Paracetamol induced Albino rat hepatotoxicity model. Animal study was done at animal house of Govt Ayurveda College, Thiruvananthapuram. Thirty albino rats were divided into seven groups. Group I-serves as normal control. Hepatotoxicity was induced by administering Paracetamol on the 7th day, and prior to that all animals received the given treatments as follows, Group II – on distilled water, and Group III – on the standard drug Silymarin (100 mg/kg), Group IV received the therapeutic dose of Kshara of male inflorescence of Borassus flabellifer along with guda(52 mg/kg b.w each), Group V received the double dose of Kshara of male inflorescence of Borassus flabellifer along with guda (104 mg/kg b.w each), Group VI received hydroalcoholic extract (500 mg/kg b.w) and Group VII received Guda(104 mg/kg). After 24 hours of administration of Paracetamol, the animals were euthanized. Effect was assessed by doing biochemical analysis of blood and histopathology of liver.  The results were analysed by One-way ANOVA followed by Tukey HSD post hoc multiple comparison test. The paracetamol treatment caused significant elevation in serum level of SGOT, SGPT, ALP & serum bilirubin and reduction in total protein & albumin levels. However, the animals treated with standard drug and study drug did not show an elevation in the biochemical values as compared to paracetamol treated group(p<0.01). In the histopathology of liver, extent of damage was minimal and hepatic regeneration was noted in study drug  treated group(G4 &G6) and standard drug treated group(G3) as compared to paracetamol treated group(G2). Among the test drug treated groups, statistically more effective result was seen in hydroalcoholic extract treated group(G6) when compared to PCM group. Further a ‘limit test’ performed in accordance with OECD guideline 425(acute toxicity) indicated that dose upto 2000mg/kg is safe.Hence it was concluded that the male inflorescence of Borassus flabellifer has significant hepatoprotective effect and it can be developed into safe herbal hepatoprotective drug.

 Key words: Liver, Borassus flabellifer Linn, Tala, Panaviral, Yakrut, Liver diseases

NAME OF SECOND PRESENTEE : Dr.SANGEETHA P.V

DISSERTATION TITLE :  Wound Healing Activity Of Pullani (Calycopteris floribunda Lam ) in albino rats.

Name of Guide     :   Dr Indulekha V C                                                                  

DATE                   :   19/6/2024

Time                   :      2 30 pm

Venue                 :    college auditorium 

                                                         ABSTRACT

Introduction: Wound is defined as the cellular and anatomic disruption of a tissue. Wound healing is a complex and dynamic process of restoring cellular structures. The process involves haemostasis, inflammation, proliferation and remodelling with scar tissue formation. Pullani is Malayalam name of a plant, identified as Calycopteris floribunda Lam. according to Ayurveda pharmacopeia of India (API). Keraleeya Oushadha Vijnana, (a compilation on Oushadha yogas from different manuscripts) mentions Pullani among the Vrana-ropana (wound healing) formulation Jatyadi gritha. In ethnomedicine its leaves are used for treating wounds & cuts.  Hence present study intended to determine wound healing activity of the ghee prepared with leaves of Pullani and with hydroalcoholic extract of Pullani by excision wound model in albino rats.

Materials & methods: Leaves of Pullani are collected from natural habitat, authenticated and the pharmacognostical, physicochemical analysis carried out. Preparation & preliminary standardisation of Pullani ghrita was done as per AFI. In vivo Excision wound study was done to assess rate of wound contraction, period of epithelization, and histopathological analysis. The rats were divided into six groups containing 5 each. Excision wounds of 2.5cm diameter and 0.2cm depth were made on the dorsal side of pre anesthetised rats. Group 1 served as control (untreated group), group 2 as standard (povidone iodine), group 3 were treated with Pullani ghritha, group 4 with plain ghritha, group 5 with Pullani ointment & group 6 served as vehicle control(ghee+beeswax). Topical application done for 14 days; wound area recorded on alternate days & rate of contraction calculated. CAM (Chick chorio Allantoic Membrane) assay was used for assessing angiogenetic potential of the drug.

Result: The statistical analysis of rate of wound contraction showed significant contraction in group 3, group 4, group 5 (p<0.001) compared to standard on day 14, highest for group 3 with mean 99.4 and SD 0.09. Period of epithelialization is least for group 3 with mean 9.4 days and SD 1.14(p<0.001) compared to untreated group & group 6 (12±0.70). Awaiting histopathology result and CAM assay analysis.

Key words: Wound healing, Pullani, Calycopteris floribunda Lam., Excision wound model, Angiogenesis, CAM assay.

NAME OF THIRD PRESENTEE : Dr.NIBISHA C P

 

DISSERTATION TITLE : Nephroprotective effect of Triphaladi compound in albino rats.

Name of Guide     :   Dr Indulekha V C                                                                  

DATE                   :   19/6/2024

Time                   :      3  pm

Venue                 :    college auditorium 

                                                                 ABSTRACT

Introduction: Chronic kidney disease (CKD) regarded as the gradual impairment of kidney function subsequently with the retention of nitrogenous and other waste products and often accompanied by reduction in urine volume. Diabetes mellitus being a global epidemic with approximately 40% of the patients resulting in diabetic nephropathy (DN). There is a need for development and further clinical application of the safe natural drugs for the prevention and treatment of DN. DN, one of the riskiest microvascular complications of diabetes mellitus (DM) patients, is believed to be the primary cause of end-stage renal failure and chronic kidney disease. Triphaladi compound (TC) is an ayurvedic polyherbal formulation described in Susrutha samhitha (Phena-meham) having 5 ingredients- fruit rind of Haritaki (Terminalia chebula Retz), Vibheetaki (Terminalia belerica Roxb), Amalaki (Emblica officinalis Gaertn), fruit pulp of   Aragvadha (Cassia fistula Linn) and fruit of Draksha (Vitis vinifera Linn). It is the 2 times potentiated powder of these ingredients in its own decoction.

Materials & methods: The present study was intended to study the Nephroprotective effect of processed Triphaladi compound in High fat diet & streptozotocin induced diabetes & DN in albino rats. The Pharmacognostical, Preliminary Physical, Phytochemical & Qualitative Analysis of TC was conducted in Drug Standardization Unit (DSU), Govt.Ayurveda College, Thiruvananthapuram.30 albino rats was divided into six groups with five rats in each group. Group I will be kept as normal control group. After 7 days of acclimatization, 25 animals were given high fat diet for 21 days, after that they were injected with streptozotocin (40mg/kg). On 3rd day FBS was checked and those with blood glucose level between 200 mg/dl & 400 mg/dl was further divided into 5 groups. Group II- disease control on distilled water, Group III were Metformin (500µg/kg) as standard drug, Group IV was   churna of Triphaladi compound (0.108g/200g rat) and Group V was   given double dose of churna of Triphaladi compound (0.216g/200g rat) and Group VI were given the hydroalcoholic extract of Triphaladi compound (500 mg/kg) for next 21 days. On 22 nd day all the animals were sacrificed and nephroprotective effect of Triphaladi compound was evaluated by blood, urine, kidney& pancreas tissues were collected for various experimental analyses.

Results: Both the HAE and therapeutic dose of TC significant decrease in BUN, HAE, therapeutic dose & double dose of TC significant decrease in serum creatinine, double dose & HAE of TC reduces FBS, double dose & therapeutic dose reduces urine creatinine & urinary protein when compared with standard drug metformin. Data will be statistically analysed using appropriate statistical technique.

Discussion& conclusion: From the results, it can be concluded that HAE, double dose & therapeutic dose of TC has a significant nephroprotective effect because of its capability to reduce the renal parameters.

 Keywords: Nephrotoxicity, Triphaladi compound, Streptozotocin.

     INTIMATION FOR BODHIKA SEMINAR 

                               12/6/2024

DEPARTMENT OF AGADATANTRA

NAME OF FIRST PRESENTEE : Dr.KEERTHY   S L

   DISSERTATION TITLE : EFFECT OF KULAKADI KASHAYA AND DOOSHIVISHARI AGADA ALONG WITH EXTERNAL APPLICATION OF SATADHOUTA GHRITA IN THE MANAGEMENT OF CHRONIC URTICARIA.

Name of Guide     :    Dr Seemaja G                                                                 

Name of co-guide  :  Dr E Anusankar     

DATE                   :   12/6/2024

Time                   :      2 pm

Venue                 :    college auditorium 

                                                                   ABSTRACT

                            Immune system plays a crucial role in maintaining health and protecting the human body against microbial invasions. However, immune system can lead to exaggerated immune and inflammatory responses resulting in adverse outcomes.Urticaria is a common  dermatological manifestation affecting 15% or more on at least once in their life time. It is defined as transient erythematous swelling of the skin associated with itching, which usually resolves within 24 hours which can be acute or chronic. Chronic urticaria is a debilitating disease characterised by itching or wheals with or without angioedema lasting for more than 6 weeks and interferes with routine activities thereby affects the quality of life. In Ayurveda allergic manifestation are mentioned due to exposure of asatmyaaharavihara, virudhahara and dooshivisa. The symptomatology and causative factors of urticaria can be compared with the Seetapitta Udarda Kota. Brihatthrayees have not detailed about seethapitha, udarda but the symptoms of allergic manifestation mentioned as Kota. In Chikitsamanjeri Seetapitta chikitsaadhyaya ‘Visarpa Chikitsa’ is mentioned for Seetapitta. So Kulakadikashaya explained in Sahasrayoga Visarpavisphotachikitsa is taken for study. Dooshivishachikitsa is incorporated in the management of urticaria hence Dooshivishari agada selected. During the episode of urticarial symptoms the persons feel distress, to reduce that the selected formulation is Satadhouta ghrita for external application mentioned in Visavaidyajyotsnika stavaravisaprathesheda. This study  is to evaluate the internal administration of 48 ml  Kulakadikashaya  twice daily before food and 6 gram of Dooshivishariagada with madhu  twice daily after food along with external application of Satadhouta ghrita for a period of 45 days in the participants aged 18-60 years effective in reducing the signs and symptoms of chronic urticaria fulfilling inclusion and exclusion criteria attending OPD,department of Agada tantra Govt Ayurveda College Thiruvananthapuram. Urticarial activity score and Chronic Urticaria Quality of Life Questionaire are assessing. Data will be statistically analysed using appropriate statistical technique.

 

Keywords:chronic urticaria,seetapittaudardakota,Kulakadikashaya,Dooshivishariagada and Satadhouta ghrita

 NAME OF SECOND PRESENTEE : Dr.SREETHU KRISHNAN R J

 

DISSERTATION TITLE : EFFECT OF EXTERNAL APPLICATION OF CHITRAKADI TAILA ALONG WITH INTERNAL ADMINISTRATION OF PATOLADI GANA KASHAYA IN TINEA CORPORIS

NAME OF GUIDE  :  Dr. PRASANTH S R

DATE                       :  12/6/2024

TIME                       :   2.30PM

VENUE                   :   College Auditorium

                                        

                                                                   ABSTRACT

Tinea corporis is a widely seen dermatological manifestation encountered in daily clinical practices. Tinea corporis is ring worm of the glabrous skin. By definition it includes lesion of the trunk and limbs, excluding ring worm of specialized sites such as the scalp, feet, and groins.  It may be transmitted by direct contact with other infected individuals or by infected animals. It is not a life-threatening condition but it affects the daily activities of human being. The signs and symptoms of tinea corporis can be correlated with dadru based on its pattern of spreading, morphology of lesion, itching and chronicity. Dadru is classified under KshudraKushta by Charka Samhita and under MahaKushta by SusruthaSamhitha and AshtangaHridaya. The fungus grows best in warm moist environment. Thus, recurrence of dermatophytosis is very common. Hence proper research is needed for the effective management of this disease. The study drug Chitrakadi taila is mentioned in kushta chikitsa chapter of yogaratnakara. Chitrakadi taila consist of chitraka, karaveera and vidanga by its tikshna and krimighna property can give quicker effect. The primary objective of this study is to evaluate the effect of Chitrakadi taila and Patoladigana Kashaya in tinea corporis. It is a pre and post interventional study with a sample size of 26 within the age group of 20-60 years. The participants satisfying inclusion criteria are selected from OPD of Department of Agadathantra, Govt. ayurveda college Thiruvananthapuram. The trial drug Chitrakadi taila and coarse powder of Padoladi gana Kashaya were given for a period of 30 days. Data collected before and after treatment, scored and statistically analysed using appropriate statistical technique.

Key word: Tinea corporis, Chitrakadi taila, Padoladi gana Kashaya

 NAME OF THIRD PRESENTEE : Dr.ARYA T

DISSERTATION TITLE : A COMPARATIVE CLINICAL TRIAL TO ASSESS THE EFFECTIVENESS OF PUNARNAVADI GHRITA ALONG WITH LIFESTYLE MODIFICATIONS TO IMPROVE THE QUALITY OF LIFE OF PARTICIPANTS WITH ALCOHOL USE DISORDER.

NAME OF GUIDE        :     Dr Shiji R S

NAME OF CO-GUIDE :     Dr Najeeb S

DATE                             :     12/6/2024

TIME                             :     3PM

VENUE                         :    College auditorium

                                                                  ABSTRACT

Alcohol is a toxic and psychoactive substance with dependence-producing properties. According to WHO, in India, the prevalence of alcohol use disorder (AUD) in men and women above the age of fifteen were 9.1% and 0.5% respectively In the Diagnostic and Statistical Manual of Mental Disorders (DSM)-5, alcohol use disorder(AUD) is “a problematic pattern of alcohol use leading to clinically significant impairment or distress, as manifested by at least two of the criteria, occurring within a 12- month period”. The previous categories of alcohol abuse and alcohol dependence used by DSM-4 were integrated into a single-word AUD with mild, moderate, and severe subclassifications. Acharya Chakradatta has mentioned the use of Punarnavadi ghrita in the management of madatyaya which is taken for the present study. Here a comparative clinical trial is designed to evaluate the effectiveness of Punarvadi ghrita and lifestyle modifications to improve the quality of life of participants with AUD. The study will be carried out in OPD, Department of Agada tantra, Govt Ayurveda College, Thiruvananthapuram, and Simans Hospital and De-addiction center, Kazhakkoottam, Thiruvananthapuram. 34 Participants satisfying the DSM-5 diagnostic criteria for AUD coming under the age group of 18-60 years after de-addiction treatment will be selected for this study. For 17 study group participants, treatment was started by giving Avipathi churna 10g with honey in the morning at 8 am one day before snehapana. From the second day onwards the trial drug Punarnavadi ghrita was given in the dose of 10-20ml considering agni and kosha with lukewarm water twice daily on an empty stomach when the participants feel hungry for a period of 30 days. Selected lifestyle modification advice will be followed in both the study and the control group for the duration of 46 days. The quality of life was assessed using the WHO QOL BREF score on the 0th day, on the16th day, on the 32nd day, and on the 47th day. The data will be collected and statistically analysed using repeated measures ANOVA.

 Keywords: Alcohol use disorder, Punarnavadi ghrita, Avipathi churna