INTIMATION FOR BODHIKA SEMINAR 24/07/2024
DEPARTMENT OF RASASASTRA & BHAISHAJYA KALPANA
NAME OF FIRST PRESENTEE: Dr Anju M
DISSERTATION TITLE: CARDIOPROTECTIVE EFFECT OF PRABHAKARA VATI IN ISOPROTERENOL INDUCED MYOCARDIAL INFARCTION IN WISTAR ALBINO RATS
TIME: 2:00-4:00 PM
VENUE: COLLEGE AUDITORIUM
ABSTRACT
Myocardial infarction (MI) remains a significant global health concern, contributing to substantial morbidity and mortality. Based on WHO reports, over 3 million people are affected by MI worldwide, and more than 1 million deaths occur annually. Prabhakara Vati, one of the formulations mentioned in Bhaishajya Ratnavali Hridroga Chikitsa, has potential cardioprotective effects. In this study, we investigate the protective role of Prabhakara Vati against isoproterenol (IS0)-induced myocardial infarction in male Wistar albino rats. Rats were divided into six groups, each containing six rats. As normal control, IS0 control, pretreatment with propranolol (10 mg/kg) as positive control, and pretreatment with Prabhakara vati (low, therapeutic, high dose) for 21 days orally. MI was induced in all groups except the normal control, with concurrent subcutaneous injections of ISO (50 mg/kg at 24 intervals) on the 20th and 21st days. Blood samples were collected on the 22nd day, the animals were sacrificed, their hearts were taken out, and they were processed right away for histopathological examinations. Cardiac biomarkers like troponin, creatine kinase (CK-MB), and lactate dehydrogenase (LDH) were assessed to determine the effect.
Results show the ISO control group presented with a significant increase in serum marker enzymes compared to the normal group. In its therapeutic and double doses, pre-treatment with Prabhakara vati shows reduced biomarker levels in ISO-induced MI groups compared to the ISO control group.
Keywords: Myocardial infarction, Prabhakara vati, Isoproterenol, Propranolol, Cardiac biomarkers
1. PG Scholar, Dept. of Rasasastra and Bhaishajya Kalpana, Government Ayurveda College, Thiruvananthapuram. 2. Assistant professor, Dept of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Science, Mannuthy. 3. Associate professor, Dept. of Rasasastra and Bhaishajya Kalpana, Government Ayurveda College, Thiruvananthapuram.
NAME OF SECOND PRESENTEE : Dr.SHILPA S
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Name of Guide : Dr R Rajam
DATE : 24/7/2024
Time : 2 pm
Venue : college auditorium
ABSTRACT
Aristas are alcoholic formulations in liquid form processed by the method of fermentation. The
self-generated alcohol acts as self-preservative. Palatability and long shelf life make it a widely
accepted dosage form. A study conducted on Dasamoolarista by Nishna K P et.al and Balarista by
Chandan Das et.al confirmed the presence of Sodium Benzoate in varying proportions in the
commercially available market samples. So if Aristas are self-preserved, then there is no need to
add preservatives. None of the manufacturing companies admit the use of preservatives in their
Aristas. Many industries fail to follow proper standards for fermentation. Souring, inadequate
fermentation, secondary fermentation and low alcohol content are the major problems faced during
large scale preparation of Aristas.
The study is a cross-sectional survey among the company outlets regarding the most demanded
Aristas and pharmaceutical companies for preservatives used in it. As per the results of initial
survey three Aristas - Jeerakarista, Abhayarista and Balarista were selected based on the frequency
of purchase and demand in the market. For the study, five market samples of each of the three
selected Aristas and its prepared samples of were analyzed. Preservatives in market samples were
analyzed by HPLC (High-Performance Thin Layer Chromatography).Out of the total 17 market
samples, 13 samples showed the presence of Sodium Benzoate. The prepared samples were
compared with market samples for Physicochemical and Phytochemical parameters.
Keywords: Aristas, Abhayarista, Balarista, Jeerakarista, Preservatives, Fermentation.
1. Final MD Scholar, Department of Rasasastra and Bhaishajya Kalpana, Government
Ayurveda College, Thiruvananthapuram.
2. Professor and HOD, Department of Rasasastra and Bhaishajya Kalpana, Government
Ayurveda College, Thiruvananthapuram.
NAME OF THIRD PRESENTEE : Dr.SARANYA N S
DATE : 24/7/2024
Time : 2 pm
Venue : college auditorium
ABSTRACT
In the recent scenario of increasing global acceptance of Ayurvedic formulations, their standardisation become more relevant. Tailas being lipid based dosage forms, the three pakas ( stages of preparation) of which is intended for different routes of administration are to be standardised with the contemporary parameters .The objective of this study is to assess whether there are any changes happening in physicochemical and phytochemical parameters among the three pakas of a taila, to standardise the preparation of each stage and to compare it with the market samples. Also to assess the changes in the physicochemical parameters of a taila when the dravadravya is changed from swarasa to Kashaya.
Here we have selected Vacha lasunadi taila, mentioned in Sahasrayoga, Taila prakarana with Vacha, Lasuna, Haridra are the Kalka dravya, Tila taila as Sneha dravya and Bilwa pathra swarasa as the Daravadravya. The study design is Analytical study and Standard analytical protocol proposed by Pharmacopoeial Laboratory for Indian Medicine and Ayurvedic Pharmacopoea of India is the study tool.
The results show that there are considerable changes occurred among the three pakas in acid value, moisture content, iodine value and saponification value. Also identified a critical control point of temperature at which the taila attained each stage during the preparation. Significant changes has also been noted in the analytical parameters of the prepared samples on comparison with the market samples
Key words: Standardisation, Sneha kalpana, Vacha, Lasuna, Haridra, Bilwa pathra Swarasa, Tila taila, Vacha lasunadi thaila
1. Final MD Scholar, Department of Rasasasthra and Bhaishajya kalpana, Government Ayurveda college, Thiruvanananthapuram
2. Professor, Department of Rasasasthra and Bhaishajya kalpana, Government Ayurveda college, Thiruvanananthapuram
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