INTIMATION FOR BODHIKA SEMINAR - 20/07/2022

DEPARTMENTS OF DRAVYA GUNA VIJNANAM

GOVT. AYURVEDA COLLEGE, THIRUVANANTHAPURAM

NAME  OF  FIRST PRESENTEE: Dr MADONNA PHILIPOSE

THESIS TITLE: Efficacy of patoladi yogam as add on medication  in Type 2 Diabetes mellitus subjects  on metformin monotherapy – A randomized placebo controlled clinical trial

NAME OF GUIDE: Dr M S DEEPA

DATE:20/07/2022

TIME: 2:00-4:00 PM

VENUE: HYBRID / MICROSOFT TEAMS 

ABSTRACT

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia due to impaired insulin  secretion or utilization or both in human body. Diabetes mellitus and its  associated complications have been posing a major threat to the health status of a large population in both developing and developed countries since decades. The major types of diabetes mellitus are type 1 and type 2.Type 2 diabetes mellitus also known as non-insulin dependent diabetes, results from body’s inefficient use of insulin and affects the vast majority. The prevalence of diabetes in adults of 20-79 years  in India is 8.3% . In Ayurveda diabetes can be considered as prameha symptomatically. In the Ayurvedic classics ,a large number of herbal preparations are mentioned in the contexts pertaining to treatment of prameha ,many of which are still left unexplored and scientifically validate .The study drug patoladi yogam is a polyherbal formulation mentioned in one of the classical Ayurveda texts, Ashtanga hridaya in the chapter of treatment of prameha. The constituent herbs of the formulation are patola (Trichosanthes dioica Roxb) ,nimba(Azadirachta indica A.Juss),amalaki(Embilica officinalis Gaertn) and amrutha(Tinospora cordifolia Miers) having  tridosahara,kandughna,rasayana and pramehaghna properties respectively, that can be effective in mitigating the longterm complications associated with DM. Preliminary phytochemical analysis of the study drug was  done. The study is  interventional RCT . Both male and female participants of age group 25-60 years  with FBS level from 126-200 mg/dl, PPBS level from 200-250 mg/dl ,HbA1c level from 6.5%- 8.5%  taking metformin monotherapy, attending OPD of Govt.Ayurveda College, Thiruvananthapuram were selected   for the study. Participants with major systemic illness and complications were excluded. The study population was divided into two groups as experimental and control groups. The study drug patoladi yoga was powdered and potentiated in its  own decoction and made into 500 mg capsules. It was dispensed to the patients of experimental group  .The control group was given similar capsules of  placebo.  The participants of both the group  were advised to take 2 capsules each thrice daily before food for a period of 90 days.  The required laboratory investigations FBS,PPBS,HbA1c were done before and after the study period. The collected data after completion of trial will be subjected to statistical analysis using appropriate statistical techniques. Results will be drawn ,summarized and conclusions will be made.