INTIMATION FOR BODHIKA SEMINAR - 13/07/2022

DEPARTMENTS OF AGADA TANTRA & RASA SHASTRA AND BHAISHAJYA KALPANA

GOVT. AYURVEDA COLLEGE, THIRUVANANTHAPURAM

NAME  OF  FIRST PRESENTEE: Dr ANU MARIAM VARGHESE

THESIS TITLE:NEPHROPROTECTIVE EFFECT OF SUGANDHADI AGADA ON CISPLATIN INDUCED NEPHROTOXICITY IN MALE WISTAR RATS

NAME OF GUIDE: Dr JAYASREE M N

NAME OF CO-GUIDE: Dr SURAJ K

DATE:13/07/2022

TIME: 2:00-4:00 PM

VENUE: HYBRID / MICROSOFT TEAMS 

ABSTRACT

In the current scenario drug induced toxicity is a major headache to the health sector limiting the usefulness of widely used agents. The development of severe, drug related complications may require premature drug withdrawal or dose reduction. In some cases, toxicity occurs in majority of treated individuals because of the nature of the drug (e.g. cytotoxic agents used for cancer-chemotherapy). Cisplatin (Cis-diamminedichloroplatinum II) is one of the most widely used and highly effective chemotherapeutic agents. Its treatment has been linked to various toxic side effects including nephrotoxicity, myelosuppression, cardiotoxicity etc. Acute kidney injury occurs in 21-31.55% patients receiving cisplatin-based chemotherapy. Now worldwide, 850 million people are estimated to have kidney diseases from various causes and are the 10^th fastest growing cause of death. In this study we are aiming to provide relief to patients on cisplatin medication. For this purpose, Sugandhadi agada, a formulation mentioned under mandali visha prakarana of Ashtanga Hridaya, Uttarasthana Sarpavisha Prathishedha is selected. Mandali Visha can be correlated to Viper envenomation by its signs and symptoms, the mode of death etc. In Viper envenomation, the mainly affected system is circulatory system and death may be due to acute renal failure. Therefore, the treatment will definitely target the circulatory and renal system. Hence, this work aims to study the nephroprotective effect of the formulation mentioned under mandali visha prakarana to tackle the aftereffects of xenobiotics causing nephrotoxicity. Physico-chemical analysis of the formulation was conducted at Department of Chemistry, Siddha Regional Research Institute, Poojappura Thiruvananthapuram and Sophisticated Test and Instrumentation Centre (STIC), CUSAT. The experimental study was conducted at Amala Cancer Research Center, Thrissur. Male wistar rats weighing 150-200g purchased from authentic breeding centers and were divided into 6 groups containing 6 animals each. The groups selected for the study are; normal, vehicle control, Cisplatin (7mg/ kg body wt.), Sugandhadi agada at high, therapeutic and low doses along with cisplatin. All the groups received their respective drugs for 14 days, except Cisplatin which was given on 10th day. Changes in the animals observed and animal sacrificed at the end of 14th day. Changes in hematological parameters- serum urea, serum creatinine, serum uric acid, serum alkaline phosphatase, serum bilirubin were assessed after collecting blood through heart puncture. Enzymatic activities along with histopathological changes in kidney were also evaluated. Results were statistically analyzed by one way ANOVA, followed by Tukey’s multiple comparison tests as post-hoc test. The overall result suggests that the Sugandhadi agada has no significant nephroprotective effects against cisplatin induced nephrotoxicity in this study.

NAME  OF  SECOND PRESENTEE: Dr LAKSHMI P N

THESIS TITLE:MARKET SAMPLE ANALYSIS OF PANCHAGAVYA GHRITHA MANUFACTURED BY GMP CERTIFIED AYURVEDIC COMPANIES IN KERALA

NAME OF GUIDE: Dr SREENI T V

NAME OF CO-GUIDE: Dr C V MEENA

DATE:13/07/2022

TIME: 2:00-4:00 PM

VENUE: HYBRID / MICROSOFT TEAMS 

ABSTRACT

Panchagavya Ghritha is a widely used Ayurvedic formulation mentioned in Ashtanga Hridaya Utharastana Apasmara Patishedha indicated in conditions like Apasmara(epilepsy),Jwara(pyrexia), and Kamala(jaundice). It contains 5 ingredients  namely goshakrit rasa(cowdung juice),amladadhi(sour curd), go ksheera(cow’s milk),gomutra(cow’s urine) and go ghritha(ghee). Authentic sources of cow products are not often obtained and found adultered. .Collection and processing of   fresh raw materials are an important area in this formulation This study was conducted to find out the non conformances and quality issues in Panchagavya ghritha production in industrial level. Methodology of the study comprises a cross sectional survey, Preparation of the Panchagavya ghritha samples and analysis of prepared and Market samples. The survey reveals that most of the companies procure raw materials from various sources and the analysis of the ingredients are not often carried out. The Market sample analysis reveals the variation in different organoleptic characters like colour,odour and texture. The physicochemical value of the different parameters among different companies was statistically analysed with ANOVA test and Scheffe’s pairwise comparison, shows significant variation among market samples and those of prepared samples were also found to be significant at 0.01 levels. HPTLC analysis shows the similar peaks in prepared and market samples. Qualitative analysis for test for Mineral oil for prepared and market sample , revealed presence of mineral oil  as an adulterant in one among the Market sample .This confirms the existence of quality issues with lack of strengthened quality assurance standardization, hence  to ensure uniform  Panchagavya ghritha production gains significance in Kerala to safety and efficacy for all the market samples.