INTIMATION FOR BODHIKA SEMINAR 27/09/2023
DEPARTMENT OF AGATHA THANTRA
GOVT. AYURVEDA COLLEGE, THIRUVANANTHAPURAM
NAME OF FIRST PRESENTEE: Dr. VIJAYALAKSHMI D
DISSERTATION TITLE:PHYSICOCHEMICAL EVALUATION OF KUPEELU SEED (STRYCHNOS NUXVOMICA Linn.) WITH DIFFERENT SODHANA METHODS
TIME: 2:00-4:00 PM
VENUE: COLLEGE AUDITORIUM
ABSTRACT
Ayurveda is
one of the world’s oldest medical systems and remains as one of India’s
traditional health care systems. Most of the Ayurvedic formulations are herbal,
some of the formulation contain poisonous drugs also. It is essential to do the
sodhana of these toxic drugs before using it therapeutically. The concept of
sodhana not only means the removal of physical and chemical impurities but also
minimizing the side effects of the drugs and thereby making the drug capable
for pharmaceutical preparation. Kupeelu is described under upavisha varga whose
seeds have been used against a number of diseases after proper sodhana. It is a
spinal poison that acts particularly on the anterior horn cell of the spinal
cord. It is a CNS stimulant, producing excitation of all portions of the
nervous system. Convulsions are produced due to direct action on the reflex
Centre of the spinal cord and affects all muscles at a time. So, it is very
essential to remove the physicaland chemical impurities of kupeelu by proper
sodhana methods before using it therapeutically. Different sodhana methods for Kupeelu
have been mentioned in Ayurvedic classics such as Rasa tarangani,
Yogaratnakara, Kriyakoumadi etc. Various media have been mentioned in textbooks
such as godugdham, tanduliya swarasam, kataka kwatha, takra, gomutra, gogrutha
etc. In this study the media used for sodhana procedures were godugdham,
gogrutham, gomootram, takram, and kanjikam. Aim of the study is to establish
the physicochemical changes occurring in kupeelu after sodhana and also to
analyze the rawkupeelu sample with sodhita kupeelu in different media. After
sodhana procedures, chemical constituents were analyzed by Thin Layer
Chromatography (TLC). Then quantitative analysis was done by using High
Performance Thin Layer Chromatography (HPTLC). The quantities of Strychnine and
brucine before and after purification were analyzed with paired t test and the
comparison between each sample of purified kupeelu was made using one way
ANOVA. Significant decrease in the quantity of brucine was found in the kupeelu
purified in (Go mutram+ Go ksheeram), takram and Danyamlam (p<0.001).
Significant decrease in the amount of strychnine was observed in the Kupeelu
purified with go ksheeram, go mutram, Danyamlam, Takram, go ghrutham all
exhibit highly significant mean difference (p<0.001) incompared with Raw
materials.







