INTIMATION FOR BODHIKA SEMINAR                                       31/05/2023

                                                DEPARTMENT OF PANCHAKARMA,

GOVT. AYURVEDA COLLEGE, THIRUVANANTHAPURAM

NAME  OF  FIRST PRESENTEE: AISWARYA R. NATH

DISSERTATION TITLE: EFFECT OF RASNADI VASTHI IN REDUCING DISEASE ACTIVITY OF RHEUMATOID ARTHRITIS

NAME OF GUIDE:  Dr PRAVITH N. K.  MD(Ay)

DATE:31/05/2023

TIME: 2:00-4:00 PM

VENUE: COLLEGE AUDITORIUM

ABSTRACT

 

Rheumatoid arthritis is a chronic inflammatory disorder with an autoimmune pathology affecting variety of body systems primarily the joints. It affects the lining of joints, causing painful swelling that can eventually result in bone erosion and deformity. Due to similar presentations Rheumatoid arthritis can be correlated with Amavata mentioned in our classics.

In Ayurveda principles of treatment of amavata are langhana, swedana and drugs having tikta, katurasa, deepana, virechana, snehapana and vasti. Vasthi karma is the best therapy to treat all the vatavyadhi . In pain and swelling of Rheumatoid arthritis nirooha vasthi which have the agni deepana , pachaka, vatakaphahara and shoola sothahara properties are essential , Rasnadi vasthi mentioned by chakrapani commentary on charaka Samhitha is one among them.

Objective of this study is to evaluate the effect of Rasnadi vasthi administered continuously for 7 days in Rheumatoid arthritis patients. The study will be a before and after study. Participants of both sex aged 30 to 60 registered in IPD of Government Ayurveda Panchakarma Hospital, Poojappura, Thiruvananthapuram diagnosed to have Rheumatoid arthritis and satisfying inclusion criteria will be selected. The base line data will be collected through interview, observation and questionnaire. After collecting base line data, detailed history and examination will be done using clinical case proforma.

 

A total of 20 participants will be selected by consecutive sampling and Rasnadi vasthi will be done continuously for 7 days. The participants will be assessed before and after the intervention (ie, on 0th, 8^th Days) with regards to changes in DAS 28 Scale and VAS. Data will be Statistically Analysed and Presented.

  INTIMATION FOR BODHIKA SEMINAR                                       24/05/2023

                                                DEPARTMENT OF KAYACHIKITSA,

GOVT. AYURVEDA COLLEGE, THIRUVANANTHAPURAM

NAME  OF  FIRST PRESENTEE: Dr.Divin V

DISSERTATION TITLE:  EFFECT OF VISHWAADI CHURNAM IN CLINICAL DEPRESSION.

NAME OF GUIDE:  Dr. Suneeshmon M S MD(Ay)

NAME OF CO-GUIDE: Dr.Kirankumar S (MBBS,DPM,DNB)

DATE:24/05/2023

TIME: 2:00-4:00 PM

VENUE: COLLEGE AUDITORIUM

                                                              ABSTRACT

Everyone experiences sadness and unhappiness at some point in their lives. Clinical depression, however, is more intense and of longer duration than typical sadness or grief, which interferes with a person’s ability to engage in daily activities. Depression has a greater impact on community than many physical illnesses. It is the leading cause of disability worldwide, and is a major contributor to the overall global burden of disease. Ayurveda provides rational means for the treatment of many physical and mental disorders which are considered to be obstinate and incurable in other systems of medicine. In Ayurveda perspective, Depression can be explained under Kaphaja unmada. Vishwaadi choornam (Harita Samhita Unmada Chikitsa) has 10 drugs in it. The primary aim of the study is to evaluate the effect of Vishwaadi choornam in reducing the signs and symptoms of Depression.

It is an interventional study – pre and post without control group. Male and female patients of the age group 20 – 60 years attending the OPD of Department of Kayachikitsa, Government Ayurveda College, Thiruvananthapuram, who were diagnosed cases of Depression based on ICD 10 Criteria will be included in the study. They will be subjected to detailed clinical evaluation and the data will be recorded. The study will be conducted in a single group. Participants will be given Vishwaadi choornam, 6gm mixed with ghee, twice daily half an hour before food for a period of 60 days. Patients will be encouraged for regular visit at OPD at an interval of 15 days for uninterrupted feedback. 30 packets will be given each time (for 15 days) and a total of 120 packets will be given to the patient during study period. The clinical assessment will be done on 0^th and 61^st day using Hamilton rating scale for Depression. The result obtained will be recorded and statistically analyzed.

 INTIMATION FOR BODHIKA SEMINAR                                       17/05/2023

                                          DEPARTMENT OF KAUMARABHRITYA,

GOVT. AYURVEDA COLLEGE, THIRUVANANTHAPURAM

NAME  OF  FIRST PRESENTEE: Dr.THULASI A

DISSERTATION TITLE:  Effect of Vachadigana Kashaya in Kapha vitiated Breast milk of lactating mothers and morbidity status of infants aged 0-6 months.

NAME OF GUIDE:  Dr.M.V Anil Kumar MD(Ay)

DATE:17/05/2023

TIME: 2:00-4:00 PM

VENUE: COLLEGE AUDITORIUM

Abstract

Breast milk is the prime source of nourishment to a newborn baby. It improves the physical as well as mental strength and immunity of the baby. In Ayurveda, unique concept of sthanya dushti or milk vitiation has been described in which mother’s food and activities affect the quantity and quality of the milk. The unwholesome diet and lifestyle habits of the mother leads to vitiation of breast milk and produces various diseases in the baby. It shows that not only the treatment of baby is enough but also the treatment of vitiated breast milk is equally important as it being the cause for morbidities in infants. In Ayurveda certain herbs and formulations are specifically indicated for detoxifying the breast milk and improve the quality of milk and there by the growth of baby along with liberation from symptoms caused due to vitiation. Acharyas Vagbhata and Sushrutha have mentioned about Vachadigana as Sthanya sodhanagana. On analyzing the ingredients of the gana, it can be used in kapha dosha pradhana sthanya dusthi. This clinical study will be conducted on the lactating mothers of infants presenting with morbidities seeking treatment under the OPD of Dept of Kaumarabhritya and Well Baby Clinic of Govt Ayurveda College, Thiruvananthapuram. The study consists of two parts. In the first part, the effect of vachadi gana Kashaya given for a period of 7 days in diagnosed cases with Kapha vitiated breast milk will be measured by qualitative and quantitative breast milk analysis methods. In the second part, the effect of Vachadi Gana Kashaya in modifying the morbidity status of infants as measured by subjective symptomatic grading. The whole sample consists of 20 subjects. Vachadi gana Kashaya in the dose of 96 ml twice daily as Phanta Kashaya will be given to the study group for a period of 7 days.

 INTIMATION FOR BODHIKA SEMINAR                                       10/05/2023

                                          DEPARTMENT OF DRAVYAGUNAVIJNANIYA

GOVT. AYURVEDA COLLEGE, THIRUVANANTHAPURAM

NAME  OF  FIRST PRESENTEE: Dr.SENHA N

DISSERTATION TITLE: Efficacy of ‘Nimbadi yogam’ as an-add on medication in Type 2 Diabetes mellitus subjects on Metformin monotherapy – a randomized controlled trial.

NAME OF GUIDE:  Dr. M.S Deepa MD (Ay)

DATE:10/05/2023

TIME: 2:00-4:00 PM

VENUE: COLLEGE AUDITORIUM

                                                                         ABSTRACT

Diabetes mellitus is a metabolic disorder resulting from a defect in insulin secretion, insulin action, or both. Insulin deficiency in turn leads to chronic hyperglycemia with disturbances of carbohydrate, fat and protein metabolism. There are two main types of diabetes, type 1 (requiring insulin for survival) and type 2 (may or may not require insulin for metabolic control). Diabetes is a major health issue that has reached alarming levels today and nearly half a billion people are living with diabetes worldwide. The prevalence of Diabetes in India is 8.9%. Kerala is the diabetic capital of India with a prevalence of diabetes as high as 20% i.e. more than double the national average. Diabetes can be correlated with Prameha in Ayurveda, there are many formulations mentioned in Ayurvedic classics and they are found to have significant hypoglycemic effect. The study drug is a polyherbal formulation containing Nimba ,Ushira , Amalaki  and Haritaki, mentioned in one of the classical ayurveda texts chakradutta in the chapter of treatment of prameha. The objective of the study is to evaluate the hypoglycemic effect of Nimbadi yogam as an add-on medication in type 2 diabetes mellitus patients with inadequate glycemic control on conventional oral hypoglycemic agent Metformin alone. The study is interventional type. Both male and female subjects of age group 25-70 years with FBS level from 126-180 mg/dl, PPBS level from 200-250 mg/dl ,HbA1c level from 6.5%- 8.5% and taking Metformin monotherapy, attending OPD of Govt. Ayurveda College, Thiruvananthapuram were selected for the study. Subjects with major systemic illness and complications were excluded. The study population was divided into two groups as experimental and control groups. In this study Nimbadi yogam was dispensed in a potentiated form in which choorna of four drugs will be powdered and potentiated in the decoction of these four drugs and the resultant powder was made into 500 mg tablets. The tablet was dispensed to the subjects of experimental group along with nishakadakadhi tarpana kwatha and the control group was administered Nisakathakadi tarpana kwatha alone. The subjects of experimental group was advised to take 2 tablets thrice daily before food along with Nisakathakadi tarpana kwatha for a period of 90 days with the stable dose of Metformin. The required laboratory investigations were done before and after the study period. The study is ongoing and the collected data will be subjected to statistical analysis using appropriate statistical techniques. Results will be drawn, summarized and conclusions will be made.

 INTIMATION FOR BODHIKA SEMINAR                                   03/05/2023

                                              DEPARTMENT OF AGADATHANTRA

GOVT. AYURVEDA COLLEGE, THIRUVANANTHAPURAM

NAME  OF  FIRST PRESENTEE:Dr.Arya S Pillai

DISSERTATIONTITLE:EFFICACY OF DRAKSHADI AGADA VERSUS NIMBAPATRA AGADA IN CISPLATIN INDUCED NEPHROTOXICITY IN WISTAR RATS

NAME OF GUIDE: Dr.Seemaja G, MD (Ay), 

NAME OF co-Guide :Dr.Achuthan C. Raghavamenon, PhD

DATE:0/12/2023

TIME: 2:00-4:00 PM

VENUE: COLLEGE AUDITORIUM

                                                        ABSTRACT

Drug induced toxicity is a major health problem in the current scenario which limits the usefulness of widely used drugs. Cisplatin is one among the widely used chemo therapeutic agent which causes nephrotoxicity in approximately one third of the patients receiving it. Through this study we are aiming to provide relief to the patients who are on Cisplatin medication. For this, Drakshadi agada mentioned under the treatment of Mandali visha inSusruta Samhita

Kalpasthana Sarpadashtachikitsavijananeeyam chapter is selected. Mandali visha can be corelated with Viper envenomation by its signs and symptoms and mode of death. Viper venom is chiefly hemotoxic and death may occur due to acute renal failure. Therefore, the treatment modalities may target circulatory and renal system. Hence this study aims to prove the nephroprotective effect of Drakshadi agada to tackle the after effects of xenobiotics causing nephrotoxicity. This study also aims to compare the nephroprotective effect of Drakshadi agada with Nimbapatra agada which had proven nephroprotective activity. Physico-chemical evaluation of the formulation will be conducted at Drug Standardization Unit (DSU) Govt. Ayurveda College, Thiruvananthapuram. Before conducting clinical trial on humans, an animal experimental study is planned to conduct at Amala Cancer Research Centre, Thrissur for a period of 3 months. Wistar rats procured from authentic breeding centre will be divided into 7 groups of 6 animals each. The groups designed for the study are; normal, Cisplatin (10mg/kg body weight), Vehicle control along with Cisplatin, Drakshadi agada at high, medium and low doses along with Cisplatin (10mg/kg body weight), Nimbapatra agada standard dose along with Cisplatin. All the groups will receive their respective drugs for 14 days, except Cisplatin which is administered on 7th day. Changes in every animal will be observed each day and animals will be sacrificed at the end of 16th day. Cisplatin induced nephrotoxicity will be evaluated by histological examinations and biochemical analysis of kidney functions. Results will be statistically analyzed by ANOVA, followed by relevant post-hoc test. If the results are significant, the formulation Drakshadi agada can be further studied as a nephroprotective agent against those drugs which cause nephrotoxicity

 INTIMATION FOR BODHIKA SEMINAR                                       27/04/2023

DEPARTMENT OF SWASTHAVRITTA

GOVT. AYURVEDA COLLEGE, THIRUVANANTHAPURAM

NAME  OF  FIRST PRESENTEE: Dr.K CINI

DISSERTATION TITLE: EFFECT OF TRIPHALA KWATHA WITH YAVA SAKTHU AND MADHU AS AN ADJUNCT TO LIFESTYLE MODIFICATIONS ON BORDERLINE DYSLIPIDEMIA

NAME OF GUIDE:  Dr. V.K. SUNITHA MD(Ay)

NAME OF CO-GUIDE:Dr  SAJITHA BHADRAN MD(Ay), PhD

DATE:27/04/2023

TIME: 2:00-4:00 PM

VENUE: COLLEGE AUDITORIUM

ABSTRACT

Dyslipidemia is the imbalance of lipids such as elevation of total cholesterol or low density lipoprotein or both or low level of high density lipoprotein in circulating plasma¹. It is one among the major metabolic risk factors for Coronary Heart Disease and atherosclerotic cardiovascular disease. The prevalence of dyslipidemia is very high around 79% in India especially in the age group in between 30-60 years around which requires urgent intervention strategies to prevent and manage this principal cardiovascular risk factors. Hence treating early borderline dyslipidemia is one of the key of success in prevention of atherosclerosis and CVD. Many Interventional trials were reported to have hypolipidemic action, giving temporary relief but cause long term undesirable effects⁴. Clinical importance of herbal drugs in the management of dyslipidemia has received considerable attention in recent years.

 The study is aimed to explore the effect of Triphala kwatha with Yava Sakthu and Madhu as an adjunct to lifestyle modifications on borderline dyslipidemia. In Ayurveda, dyslipidemia can be correlated with Medodushti, a condition caused by derangement of agni. Elevated lipid profiles can be brought back to normal by kaphamedohara, deepana, rookshana and lekhana drugs.

 A Quasi experimental study is conducted in 60 participants of all sexes, satisfying inclusion and exclusion criteria. Out of 60 participants, 30 each are consecutively selected and allocated alternately to study group and control group. The study group was given 48ml Triphala kwatha with 6 g Yava sakthu and 6g Madhu twice daily one hour before food with life style modifications for 90 days while the control group was kept on lifestyle modifications alone .The outcome measurements is analysed through serum lipid profile investigations on 0^th , 45^th and 90^th day. Conclusions made accordingly by using suitable statistical analysis by paired t test and student t test. 

  INTIMATION FOR BODHIKA SEMINAR                                       05/04/2023

DEPARTMENT OF SHALYA TANTRA

GOVT. AYURVEDA COLLEGE, THIRUVANANTHAPURAM

NAME  OF  FIRST PRESENTEE: Dr.Abhirami A

DISSERTATION TITLE: A clinical study to evaluate the analgesic and antimicrobial effect of dhoopana with Sriveshtakadi dhoopa choorna in non healing ulcer

NAME OF GUIDE:  Dr P BENEDICT

NAME OF CO-GUIDE:Dr S ANEESH

DATE:05/03/2023

TIME: 2:00-4:00 PM

VENUE: COLLEGE AUDITORIUM

ABSTRACT

A Chronic ulcer may be defined as one that fails to heal in the expected time for a ulcer of that type, which is usually less than 3 weeks ^[1]. Chronic ulcers usually respond slowly to conventional treatments. In Ayurveda classics ,ulcers its types and management has been explained. Signs and symptoms of non-healing ulcers can be compared with features of Dushtavrana.Susruta Samhita Chikitsa stana 1^st chapter explains 60 methods of treatment of ulcers and dhoopana is one among them. In Susruta Samhita Sutrastana Misrakadhyaya, drugs have been mentioned for vrana dhoopana like -Sriveshtaka, Sarjarasa, Sarala, Devadaru, Saara vrikshas like asana, khadira.The aim of the study is to evaluate analgesic and antimicrobial effect of this vrana dhoopana yoga in non-healing ulcer. Dhoopana will be done for 7 days, twice a day, for 10 minutes each.This is a single group Pre and Post interventional study; sampling method is consecutive sampling and the sample size is 27. Patients of age group 30-60years having non- healing ulcers are taken irrespective of gender from OPD and IPD of the Department of Shalyatantra, Government Ayurveda College, Thiruvananthapuram, satisfying inclusion and exclusion criteria.Results will be analysed statistically after the study.